Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location Journal Article
| Authors: | Pratt, E. C.; Skubal, M.; Mc Larney, B.; Causa-Andrieu, P.; Das, S.; Sawan, P.; Araji, A.; Riedl, C.; Vyas, K.; Tuch, D.; Grimm, J. |
| Article Title: | Prospective testing of clinical Cerenkov luminescence imaging against standard-of-care nuclear imaging for tumour location |
| Abstract: | In oncology, the feasibility of Cerenkov luminescence imaging (CLI) has been assessed by imaging superficial lymph nodes in a few patients undergoing diagnostic 18F-fluoro-2-deoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). However, the weak luminescence signal requires the removal of ambient light. Here we report the development of a clinical CLI fiberscope with a lightproof enclosure, and the clinical testing of the setup using five different radiotracers. In an observational prospective trial (ClinicalTrials.gov identifier NCT03484884) involving 96 patients with existing or suspected tumours, scheduled for routine clinical FDG PET or 131I therapy, the level of agreement of CLI with standard-of-care imaging (PET or planar single-photon emission CT) for tumour location was ‘acceptable’ or higher (≥3 in the 1–5 Likert scale) for 90% of the patients. CLI correlated with the concentration of radioactive activity, and captured therapeutically relevant information from patients undergoing targeted radiotherapy or receiving the alpha emitter 223Ra, which cannot be feasibly imaged clinically. CLI could supplement radiological scans, especially when scanner capacity is limited. © 2022, The Author(s), under exclusive licence to Springer Nature Limited. |
| Keywords: | adult; controlled study; aged; major clinical study; clinical trial; cancer radiotherapy; positron emission tomography; prospective study; prospective studies; neoplasm; neoplasms; tumor localization; clinical assessment; diagnostic imaging; neuroendocrine tumor; prostate cancer; health care quality; iodine 131; luminescence; luminescent measurements; tumors; lymph node; diagnosis; radioactivity; fluorodeoxyglucose f 18; hypermetabolism; fluorodeoxyglucose f18; positron-emission tomography; observational study; patient treatment; fluorine 18; gallium 68; positrons; pancreas islet cell tumor; positron emission tomography/computed tomographies; light; single photon emission computed tomography; cerenkov; cerenkov luminescence imaging; luminescence imaging; procedures; lutetium 177; tumor location; nuclear imaging; very elderly; radium chloride ra 223; humans; human; male; female; article; particle beams; likert scale; standard of cares; positron emission tomography-computed tomography; positron emission tomography computed tomography; gallium dotatate ga 68; concentration process; prospectives; ambient light; luminescence signals; oxodotreotide lutetium lu 177 |
| Journal Title: | Nature Biomedical Engineering |
| Volume: | 6 |
| Issue: | 5 |
| ISSN: | 2157-846X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-05-01 |
| Start Page: | 559 |
| End Page: | 568 |
| Language: | English |
| DOI: | 10.1038/s41551-022-00876-4 |
| PUBMED: | 35411113 |
| PROVIDER: | scopus |
| PMCID: | PMC9149092 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2022 -- Source: Scopus |
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