Clinical Cerenkov luminescence imaging of (18)F-FDG Journal Article
| Authors: | Thorek, D. L.; Riedl, C. C.; Grimm, J. |
| Article Title: | Clinical Cerenkov luminescence imaging of (18)F-FDG |
| Abstract: | The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic (18)F-FDG scans to detect nodal disease. Patients undergoing routine (18)F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal (18)F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. The camera demonstrated linear correlation between activity and counts into the low nanocurie range using (18)F-FDG. Imaging of patients revealed the presence of (18)F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. CL imaging with diagnostic doses of (18)F-FDG is feasible and can aid in detecting disease in the clinical setting. |
| Keywords: | middle aged; positron emission tomography; methodology; radiopharmaceuticals; computer assisted tomography; cohort studies; cohort analysis; tomography, x-ray computed; time; time factors; diagnostic agent; luminescence; pilot study; pilot projects; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; radiopharmaceutical agent; photons; photon; fluorescence imaging; pet/ct; clinical; 18f-fdg; optical imaging; cerenkov luminescence imaging; multimodal imaging; humans; human; male; female; article |
| Journal Title: | Journal of Nuclear Medicine |
| Volume: | 55 |
| Issue: | 1 |
| ISSN: | 0161-5505 |
| Publisher: | Society of Nuclear Medicine |
| Date Published: | 2014-01-01 |
| Start Page: | 95 |
| End Page: | 98 |
| Language: | English |
| PUBMED: | 24078721 |
| PROVIDER: | scopus |
| PMCID: | PMC3903390 |
| DOI: | 10.2967/jnumed.113.127266 |
| DOI/URL: | |
| Notes: | Export Date: 2 April 2014 -- Source: Scopus |
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