Innovations in nuclear imaging instrumentation: Cerenkov imaging Journal Article

Authors: Tamura, R.; Pratt, E. C.; Grimm, J.
Article Title: Innovations in nuclear imaging instrumentation: Cerenkov imaging
Abstract: Cerenkov luminescence (CL) is blue glow light produced by charged subatomic particles travelling faster than the phase velocity of light in a dielectric medium such as water or tissue. CL was first discovered in 1934, but for biomedical research it was recognized only in 2009 after advances in optical camera sensors brought the required high sensitivity. Recently, applications of CL from clinical radionuclides have been rapidly expanding to include not only preclinical and clinical biomedical imaging but also an approach to therapy. Cerenkov Luminescence Imaging (CLI) utilizes CL generated from clinically relevant radionuclides alongside optical imaging instrumentation. CLI is advantageous over traditional nuclear imaging methods in terms of infrastructure cost, resolution, and imaging time. Furthermore, CLI is a truly multimodal imaging method where the same agent can be detected by two independent modalities, with optical (CL) imaging and with positron emission tomography (PET) imaging. CL has been combined with small molecules, biomolecules and nanoparticles to improve diagnosis and therapy in cancer research. Here, we cover the fundamental breakthroughs and recent advances in reagents and instrumentation methods for CLI as well as therapeutic application of CL. © 2018 Elsevier Inc.
Journal Title: Seminars in Nuclear Medicine
Volume: 48
Issue: 4
ISSN: 0001-2998
Publisher: Elsevier Inc.  
Date Published: 2018-07-01
Start Page: 359
End Page: 366
Language: English
DOI: 10.1053/j.semnuclmed.2018.02.007
PROVIDER: scopus
PUBMED: 29852945
PMCID: PMC6251708
Notes: Review -- Export Date: 2 July 2018 -- Source: Scopus
Citation Impact
MSK Authors
  1. Jan Grimm
    62 Grimm
  2. Ryo Tamura
    3 Tamura
  3. Edwin C Pratt
    4 Pratt