Altered gyrification in chemotherapy-treated older long-term breast cancer survivors Journal Article
| Authors: | Daniel, E.; Deng, F.; Patel, S. K.; Sedrak, M. S.; Kim, H.; Razavi, M.; Sun, C. L.; Root, J. C.; Ahles, T. A.; Dale, W.; Chen, B. T. |
| Article Title: | Altered gyrification in chemotherapy-treated older long-term breast cancer survivors |
| Abstract: | Purpose: The purpose of this prospective longitudinal study was to evaluate the changes in brain surface gyrification in older long-term breast cancer survivors 5–15 years after chemotherapy treatment. Methods: Older breast cancer survivors aged ≥ 65 years treated with chemotherapy (C+) or without chemotherapy (C-) 5–15 years prior and age- and sex-matched healthy controls (HC) were recruited (time point 1 (TP1)) and followed up for 2 years (time point 2 (TP2)). Study assessments for both time points included neuropsychological (NP) testing with the NIH Toolbox cognition battery and cortical gyrification analysis based on brain MRI. Results: The study cohort with data for both TP1 and TP2 consisted of the following: 10 participants for the C+ group, 12 participants for the C- group, and 13 participants for the HC group. The C+ group had increased gyrification in six local gyral regions including the right fusiform, paracentral, precuneus, superior, middle temporal gyri and left pars opercularis gyrus, and it had decreased gyrification in two local gyral regions from TP1 to TP2 (p <.05, Bonferroni corrected). The C- and HC groups showed decreased gyrification only (p <.05, Bonferroni corrected). In the C+ group, changes in right paracentral gyrification and crystalized composite scores were negatively correlated (R = –0.76, p =.01). Conclusions: Altered gyrification could be the neural correlate of cognitive changes in older chemotherapy-treated long-term breast cancer survivors. © 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. |
| Keywords: | cancer chemotherapy; controlled study; aged; aged, 80 and over; antineoplastic agents; chemotherapy; neuroimaging; nuclear magnetic resonance imaging; follow up; magnetic resonance imaging; antineoplastic agent; prospective study; prospective studies; breast cancer; image analysis; brain cortex; cohort analysis; drug effect; pathology; diagnostic imaging; breast neoplasms; cancer survivor; questionnaire; body mass; longitudinal studies; breast tumor; scoring system; neuropsychological tests; cognition; neuropsychological assessment; drug therapy; cerebral cortex; white matter; longitudinal study; health education; electroencephalography; working memory; brain size; cancer survivors; corpus callosum; center for epidemiological studies depression scale; demographics; fractional anisotropy; medical procedures; sleep quality; executive function; very elderly; humans; human; male; female; article; cancer related cognitive impairment; birth weight; postcentral gyrus; cancer-related cognitive impairment; superior frontal gyrus; fusiform gyrus; precuneus; gyrification index; t1 weighted imaging; gyrification; lingual gyrus |
| Journal Title: | Brain and Behavior |
| Volume: | 14 |
| Issue: | 8 |
| ISSN: | 2162-3279 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-08-01 |
| Start Page: | e3634 |
| Language: | English |
| DOI: | 10.1002/brb3.3634 |
| PUBMED: | 39169605 |
| PROVIDER: | scopus |
| PMCID: | PMC11339126 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- Source: Scopus |
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