Effect of chemotherapy on hippocampal volume and shape in older long-term breast cancer survivors Journal Article
| Authors: | Daniel, E.; Deng, F.; Patel, S. K.; Sedrak, M. S.; Young, J.; Kim, H.; Razavi, M.; Sun, C. L.; Root, J. C.; Ahles, T. A.; Dale, W.; Chen, B. T. |
| Article Title: | Effect of chemotherapy on hippocampal volume and shape in older long-term breast cancer survivors |
| Abstract: | Purpose: The objective of this study was to assess changes in hippocampal volume and shape in older long-term breast cancer survivors who were exposed to chemotherapy 5–15 years prior. Methods: This study recruited female long-term breast cancer survivors aged 65 years or older with a history of chemotherapy (C+), age-matched breast cancer survivors who did not receive chemotherapy (C−), and healthy controls (HC). The participants were recruited 5–15 years after chemotherapy at time point 1 (TP1) and were followed up for 2 years at time point 2 (TP2). Assessments included hippocampal volume and shape from brain MRI scans and neuropsychological (NP) tests. Results: At TP1, each of the three groups was comprised of 20 participants. The C+ group exhibited a hippocampal volume loss estimated in proportion with total intracranial volume (ICV) in both the left and right hemispheres from TP1 to TP2. Regarding the hippocampal shape at TP1, the C+ group displayed inward changes compared to the control groups. Within the C+ group, changes in right hippocampal volume adjusted with ICV were positively correlated with crystalized composite scores (R = 0.450, p = 0.044). Additionally, in C+ groups, chronological age was negatively correlated with right hippocampal volume adjusted with ICV (R = −0.585, p = 0.007). Conclusion: The observed hippocampal volume reduction and inward shape deformation within the C+ group may serve as neural basis for cognitive changes in older long-term breast cancer survivors with history of chemotherapy treatment. Copyright © 2024 Daniel, Deng, Patel, Sedrak, Young, Kim, Razavi, Sun, Root, Ahles, Dale and Chen. |
| Keywords: | cancer chemotherapy; controlled study; aged; major clinical study; chemotherapy; follow up; breast cancer; information processing; cancer survivor; correlation analysis; data analysis; scoring system; cognitive defect; neuropsychological assessment; educational status; trastuzumab; brain function; ethnicity; normal human; race; hippocampus; volumetry; brain size; hippocampal volume; human; female; article; cancer-related cognitive impairment; t1 weighted imaging; hippocampal shape; hippocampal volumetric analysis; long term breast cancer survivor; neuropsychological composite score; total intracranial volume |
| Journal Title: | Frontiers in Aging Neuroscience |
| Volume: | 16 |
| ISSN: | 1663-4365 |
| Publisher: | Frontiers Research Foundation |
| Date Published: | 2024-03-08 |
| Start Page: | 1347721 |
| Language: | English |
| DOI: | 10.3389/fnagi.2024.1347721 |
| PROVIDER: | scopus |
| PMCID: | PMC10957749 |
| PUBMED: | 38524113 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed and PDF -- Source: Scopus |
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