Brain white matter microstructural changes in chemotherapy-treated older long-term breast cancer survivors Journal Article
| Authors: | Daniel, E.; Deng, F.; Patel, S. K.; Sedrak, M. S.; Kim, H.; Razavi, M.; Sun, C. L.; Root, J. C.; Ahles, T. A.; Dale, W.; Chen, B. T. |
| Article Title: | Brain white matter microstructural changes in chemotherapy-treated older long-term breast cancer survivors |
| Abstract: | Purpose: To assess white matter microstructural changes in older long-term breast cancer survivors 5–15 years post-chemotherapy treatment. Methods: Breast cancer survivors aged 65 years or older who underwent chemotherapy (C+) and who did not undergo chemotherapy (C−) and age- and sex-matched healthy controls (HC) were enrolled at time point 1 (TP1) and followed for 2 years for time point 2 (TP2). All participants underwent brain MRI with diffusion tensor images and neuropsychological (NP) testing with the NIH Toolbox Cognition Battery. Tract-based spatial statistics (TBSS) analysis was performed on the diffusion tensor images to assess white matter microstructural changes with the fractional anisotropy (FA) parameter. Results: There were significant longitudinal alterations in FA within the C+ group over time. The C+ group showed diminished FA in the body and genu of corpus callosum, anterior corona radiate, and external capsule on both the whole brain and region of interest (ROI) based analyses after p < 0.05 family-wise error (FWE) correction. However, there were no significant group differences between the groups at TP1. Additionally, at TP1, a positive correlation (R = 0.58, p = 0.04) was observed between the FA value of the anterior corona radiata and the crystallized composite score in the C+ group. Conclusions: Brain white matter microstructural alterations may be the underlying neural correlates of cognitive changes in older breast cancer survivors who had chemotherapy treatment years ago. © 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. |
| Keywords: | cancer chemotherapy; controlled study; aged; major clinical study; doxorubicin; fluorouracil; chemotherapy; methotrexate; nuclear magnetic resonance imaging; breast cancer; cohort analysis; cyclophosphamide; groups by age; cancer survivor; docetaxel; scoring system; neuropsychological assessment; white matter; correlational study; longitudinal study; tissue structure; sex; mental performance; corpus callosum; diffusion tensor imaging; brain tissue; fractional anisotropy; corona radiata (brain); human; female; article; cancer-related cognitive impairment; tract-based spatial statistics; external capsule |
| Journal Title: | Cancer Medicine |
| Volume: | 13 |
| Issue: | 1 |
| ISSN: | 2045-7634 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2024-01-01 |
| Start Page: | e6881 |
| Language: | English |
| DOI: | 10.1002/cam4.6881 |
| PUBMED: | 38152038 |
| PROVIDER: | scopus |
| PMCID: | PMC10807556 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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