Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: A pilot longitudinal study Journal Article
| Authors: | Chen, B. T.; Jin, T.; Patel, S. K.; Ye, N.; Ma, H.; Wong, C. W.; Rockne, R. C.; Root, J. C.; Saykin, A. J.; Ahles, T. A.; Holodny, A. I.; Prakash, N.; Mortimer, J.; Waisman, J.; Yuan, Y.; Li, D.; Sedrak, M. S.; Vazquez, J.; Katheria, V.; Dale, W. |
| Article Title: | Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: A pilot longitudinal study |
| Abstract: | Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer. Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60–82 years) with stage I–III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Fourteen age- and sex-matched healthy controls (HC) underwent the same assessments at matched intervals. Three voxel-wise rs-fMRI parameters: amplitude of low-frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity, were computed at each time point. The changes in rs-fMRI parameters from TP1 to TP2 for each group, the group differences in changes (the CT group vs. the HC group), and the group difference in the baseline rs-fMRI parameters were assessed. In addition, correlative analysis between the rs-fMRI parameters and neuropsychological testing scores was also performed. Results: In the CT group, one brain region, which included parts of the bilateral subcallosal gyri and right anterior cingulate gyrus, displayed increased ALFF from TP1 to TP2 (cluster p-corrected = 0.024); another brain region in the left precuneus displayed decreased fALFF from TP1 to TP2 (cluster level p-corrected = 0.025). No significant changes in the rs-fMRI parameters from TP1 to TP2 were observed in the HC group. Although ALFF and fALFF alterations were observed only in the CT group, none of the between-group differences in rs-fMRI parameter changes reached statistical significance. Conclusions: Our study results of ALFF and fALFF alterations in the chemotherapy-treated women suggest that adjuvant chemotherapy may affect intrinsic brain activity in older women with breast cancer. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. |
| Journal Title: | Breast Cancer Research and Treatment |
| Volume: | 176 |
| Issue: | 1 |
| ISSN: | 0167-6806 |
| Publisher: | Springer |
| Date Published: | 2019-07-01 |
| Start Page: | 181 |
| End Page: | 189 |
| Language: | English |
| DOI: | 10.1007/s10549-019-05230-y |
| PUBMED: | 30989462 |
| PROVIDER: | scopus |
| PMCID: | PMC6551279 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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