The intestinal microbiota and therapeutic responses to immunotherapy Review
| Authors: | Herrera, P. S.; van den Brink, M. |
| Review Title: | The intestinal microbiota and therapeutic responses to immunotherapy |
| Abstract: | The intestinal microbiota, a complex ecosystem of microorganisms, has emerged as an important player in modulating various aspects of human health and disease. The microbiota is in a state of constant cross talk with itself and its host, and these interactions regulate several aspects of host homeostasis, including immune responses. Studies have demonstrated a relationship between the microbiota and outcomes of several cancer immunotherapies. This review explores the different roles of intestinal microbiota in shaping the efficacy and safety of cancer immunotherapies, including allogeneic hematopoietic cell transplantation, immune checkpoint blockade, and CAR T cell therapy. Copyright © 2024 by the author(s). |
| Keywords: | treatment response; review; nonhuman; side effect; cancer immunotherapy; immune response; immunotherapy; drug combination; hematopoietic cell; drug therapy; intestine flora; adverse drug reaction; therapy; cell transplantation; allogeneic hematopoietic cell transplantation; microbiota; immune checkpoint inhibitor; human; female; dysbiosis; immune checkpoint inhibitors; chimeric antigen receptor t-cell immunotherapy; car t cell therapy; chimeric antigen receptor t-cell; allo-hct |
| Journal Title: | Annual Review of Cancer Biology |
| Volume: | 8 |
| ISSN: | 2472-3428 |
| Publisher: | Annual Reviews |
| Date Published: | 2024-01-01 |
| Start Page: | 435 |
| End Page: | 452 |
| Language: | English |
| DOI: | 10.1146/annurev-cancerbio-062722-035210 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- MSK corresponding author is Marcel van den Brink -- Source: Scopus |
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