Role of the intestinal mucosa in acute gastrointestinal GVHD Journal Article
| Authors: | Peled, J. U.; Hanash, A. M.; Jenq, R. R. |
| Article Title: | Role of the intestinal mucosa in acute gastrointestinal GVHD |
| Abstract: | Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinical trials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD. © 2016 by The American Society of Hematology. All rights reserved. |
| Keywords: | allograft; clinical trials as topic; hematopoietic stem cell transplantation; pathology; immunology; intestine flora; microbiology; graft vs host disease; acute disease; intestine mucosa; gastrointestinal diseases; clinical trial (topic); intestinal mucosa; allografts; immunity, mucosal; mucosal immunity; humans; human; gastrointestinal microbiome |
| Journal Title: | Hematology-American Society of Hematology Education Program |
| Volume: | 2016 |
| Issue: | 1 |
| ISSN: | 1520-4391 |
| Publisher: | American Society of Hematology |
| Date Published: | 2016-12-02 |
| Start Page: | 119 |
| End Page: | 127 |
| Language: | English |
| PUBMED: | 27913470 |
| PROVIDER: | scopus |
| DOI: | 10.1182/asheducation-2016.1.119 |
| PMCID: | PMC5575743 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 August 2017 -- Source: Scopus |
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