Intestinal Blautia is associated with reduced death from graft-versus-host disease Journal Article

Authors: Jenq, R. R.; Taur, Y.; Devlin, S. M.; Ponce, D. M.; Goldberg, J. D.; Ahr, K. F.; Littmann, E. R.; Ling, L.; Gobourne, A. C.; Miller, L. C.; Docampo, M. D.; Peled, J. U.; Arpaia, N.; Cross, J. R.; Peets, T. K.; Lumish, M. A.; Shono, Y.; Dudakov, J. A.; Poeck, H.; Hanash, A. M.; Barker, J. N.; Perales, M. A.; Giralt, S. A.; Pamer, E. G.; van den Brink, M. R. M.
Article Title: Intestinal Blautia is associated with reduced death from graft-versus-host disease
Abstract: The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute to GVHD pathophysiology, but recent animal studies in nontransplant settings have found that anti-inflammatory effects are mediated by certain subpopulations of intestinal commensals. Hypothesizing that a more nuanced relationship may exist between the intestinal bacteria and GVHD, we evaluated the fecal bacterial composition of 64 patients 12 days after BMT. We found that increased bacterial diversity was associated with reduced GVHD-related mortality. Furthermore, harboring increased amounts of bacteria belonging to the genus Blautia was associated with reduced GVHD lethality in this cohort and was confirmed in another independent cohort of 51 patients from the same institution. Blautia abundance was also associated with improved overall survival. We evaluated the abundance of Blautia with respect to clinical factors and found that loss of Blautia was associated with treatment with antibiotics that inhibit anaerobic bacteria and receiving total parenteral nutrition for longer durations. We conclude that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival. © 2015 American Society for Blood and Marrow Transplantation.
Keywords: adult; aged; unclassified drug; major clinical study; overall survival; mortality; treatment duration; cohort analysis; steroid; nonmyeloablative conditioning; graft versus host reaction; total parenteral nutrition; vancomycin; intestine flora; immunosuppressive treatment; calcineurin inhibitor; bone marrow transplantation; cotrimoxazole; metronidazole; antibiotic prophylaxis; feces analysis; ceftriaxone; piperacillin plus tazobactam; clindamycin; cefepime; graft-versus-host disease; intestinal bacteria; ceftazidime; cilastatin plus imipenem; meropenem; veillonella; allogeneic peripheral blood stem cell transplantation; clavulanic acid; human; male; female; article; aztreonam; clavulanate plus ticarcillin; ticarcillin; blautia
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 21
Issue: 8
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2015-08-01
Start Page: 1373
End Page: 1383
Language: English
DOI: 10.1016/j.bbmt.2015.04.016
PROVIDER: scopus
PMCID: PMC4516127
PUBMED: 25977230
Notes: Export Date: 2 September 2015 -- Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    562 Giralt
  2. Eric Pamer
    254 Pamer
  3. Alan M Hanash
    83 Hanash
  4. Doris Ponce
    135 Ponce
  5. Miguel-Angel Perales
    397 Perales
  6. Juliet N Barker
    232 Barker
  7. Jarrod Andrew Dudakov
    58 Dudakov
  8. Robert R Jenq
    103 Jenq
  9. Justin Robert Cross
    56 Cross
  10. Ying Taur
    92 Taur
  11. Yusuke Shono
    34 Shono
  12. Sean McCarthy Devlin
    322 Devlin
  13. Nicholas Arpaia
    8 Arpaia
  14. Lilan Ling
    40 Ling
  15. Jonathan U Peled
    50 Peled
  16. Hendrik Poeck
    7 Poeck
  17. Melissa   Docampo
    15 Docampo
  18. Katya Frances Ahr
    4 Ahr
  19. Liza Claire Miller
    7 Miller
  20. Tatanisha   Peets
    4 Peets
  21. Melissa Amy Lumish
    3 Lumish