Synapse - Intestinal Blautia is associated with reduced death from graft-versus-host disease

Intestinal Blautia is associated with reduced death from graft-versus-host disease Journal Article

Authors:	Jenq, R. R.; Taur, Y.; Devlin, S. M.; Ponce, D. M.; Goldberg, J. D.; Ahr, K. F.; Littmann, E. R.; Ling, L.; Gobourne, A. C.; Miller, L. C.; Docampo, M. D.; Peled, J. U.; Arpaia, N.; Cross, J. R.; Peets, T. K.; Lumish, M. A.; Shono, Y.; Dudakov, J. A.; Poeck, H.; Hanash, A. M.; Barker, J. N.; Perales, M. A.; Giralt, S. A.; Pamer, E. G.; van den Brink, M. R. M.
Article Title:	Intestinal Blautia is associated with reduced death from graft-versus-host disease
Abstract:	The relationship between intestinal microbiota composition and acute graft-versus-host disease (GVHD) after allogeneic blood/marrow transplantation (allo-BMT) is not well understood. Intestinal bacteria have long been thought to contribute to GVHD pathophysiology, but recent animal studies in nontransplant settings have found that anti-inflammatory effects are mediated by certain subpopulations of intestinal commensals. Hypothesizing that a more nuanced relationship may exist between the intestinal bacteria and GVHD, we evaluated the fecal bacterial composition of 64 patients 12 days after BMT. We found that increased bacterial diversity was associated with reduced GVHD-related mortality. Furthermore, harboring increased amounts of bacteria belonging to the genus Blautia was associated with reduced GVHD lethality in this cohort and was confirmed in another independent cohort of 51 patients from the same institution. Blautia abundance was also associated with improved overall survival. We evaluated the abundance of Blautia with respect to clinical factors and found that loss of Blautia was associated with treatment with antibiotics that inhibit anaerobic bacteria and receiving total parenteral nutrition for longer durations. We conclude that increased abundance of commensal bacteria belonging to the Blautia genus is associated with reduced lethal GVHD and improved overall survival. © 2015 American Society for Blood and Marrow Transplantation.
Keywords:	adult; aged; unclassified drug; major clinical study; overall survival; mortality; treatment duration; cohort analysis; steroid; nonmyeloablative conditioning; graft versus host reaction; total parenteral nutrition; vancomycin; intestine flora; immunosuppressive treatment; calcineurin inhibitor; bone marrow transplantation; cotrimoxazole; metronidazole; antibiotic prophylaxis; feces analysis; ceftriaxone; piperacillin plus tazobactam; clindamycin; cefepime; graft-versus-host disease; intestinal bacteria; ceftazidime; cilastatin plus imipenem; meropenem; veillonella; allogeneic peripheral blood stem cell transplantation; clavulanic acid; human; male; female; article; aztreonam; clavulanate plus ticarcillin; ticarcillin; blautia
Journal Title:	Biology of Blood and Marrow Transplantation
Volume:	21
Issue:	8
ISSN:	1083-8791
Publisher:	Elsevier Inc.
Date Published:	2015-08-01
Start Page:	1373
End Page:	1383
Language:	English
DOI:	10.1016/j.bbmt.2015.04.016
PROVIDER:	scopus
PMCID:	PMC4516127
PUBMED:	25977230
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84937701770&partnerID=40&md5=9bbbfbedb0ad856db03305ec76280864
Notes:	Export Date: 2 September 2015 -- Source: Scopus