Role of the intestinal mucosa in acute gastrointestinal GVHD Journal Article

Authors: Peled, J. U.; Hanash, A. M.; Jenq, R. R.
Article Title: Role of the intestinal mucosa in acute gastrointestinal GVHD
Abstract: Intestinal graft-versus-host disease (GVHD) remains a significant obstacle to the success of allogeneic hematopoietic cell transplantation. The intestinal mucosa comprises the inner lining of the intestinal tract and maintains close proximity with commensal microbes that reside within the intestinal lumen. Recent advances have significantly improved our understanding of the interactions between the intestinal mucosa and the enteric microbiota. Changes in host mucosal tissue and commensals posttransplant have been actively investigated, and provocative insights into mucosal immunity and the enteric microbiota are now being translated into clinicaltrials of novel approaches for preventing and treating acute GVHD. In this review, we summarize recent findings related to aspects of the intestinal mucosa during acute GVHD. © 2016 by The American Society of Hematology.
Journal Title: Blood
Volume: 128
Issue: 20
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2016-11-17
Start Page: 2395
End Page: 2402
Language: English
DOI: 10.1182/blood-2016-06-716738
PROVIDER: scopus
PMCID: PMC5114486
PUBMED: 27856471
Notes: Review -- Export Date: 2 May 2017 -- Source: Scopus
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MSK Authors
  1. Alan M Hanash
    81 Hanash
  2. Robert R Jenq
    100 Jenq
  3. Jonathan U Peled
    35 Peled