Factors affecting diagnostic yield of lesional bone biopsy in hematologic malignancy patients Journal Article
| Authors: | Cooke, T. M.; Maybody, M.; Aly, A. K.; Petre, E. N.; Santos, E.; Noy, A.; Chan, A. Y.; Lis, E.; Gangai, N.; Cornelis, F. H.; Moussa, A. M. |
| Article Title: | Factors affecting diagnostic yield of lesional bone biopsy in hematologic malignancy patients |
| Abstract: | Purpose: To evaluate factors affecting the diagnostic yield (percent of biopsy samples leading to a pathologic diagnosis) of lesional bone biopsies in patients with hematologic malignancies. Materials and Methods: This retrospective study included 206 lesional bone biopsies in 182 patients with a hematologic malignancy between January 2017 and December 2022. The parameters that were reviewed to evaluate diagnostic yield included biopsy device type (manual vs. electric-powered drill), number of biopsy cores acquired, core biopsy needle gauge, preliminary intra-procedural sample adequacy (touch preparation cytology determining if samples are adequate for final pathologic examination), lesion morphology on Computed Tomography (CT), and presence of crush artifact. Results: Review of 206 lesional biopsies showed overall diagnostic yield to be 89.8% (185/206). The two statistically significant factors affecting diagnostic yield were biopsy device type and in-room adequacy. 41/42 samples obtained with the electric-powered drill and 144/164 samples obtained using a variety of manual needles were diagnostic (97.6% vs 87.8%, p = 0.03). Of the 192 samples that were assessed for sample adequacy intra-procedurally, 97/102 of the samples that were deemed adequate were diagnostic, and 77/90 of the samples where intra-procedural adequacy was not confirmed were diagnostic (95.1% vs 85.6%, p = 0.018). The remaining factors did not affect diagnostic yield. Conclusion: The use of an electric-powered drill bone biopsy device and intra-procedural confirmation of sample adequacy are associated with a higher diagnostic yield of lesional bone biopsies in patients with hematologic malignancies. The presence or absence of crush artifact did not significantly affect the diagnostic yield in these patients. Level of Evidence IV. Graphical Abstract: [Figure not available: see fulltext.]. © 2023, Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). |
| Keywords: | retrospective studies; pathology; retrospective study; hematologic malignancy; hematologic neoplasms; biopsy, fine-needle; bone; bone and bones; hematologic disease; bone disease; bone diseases; bone biopsy; fine needle aspiration biopsy; procedures; image guided biopsy; image-guided biopsy; humans; human; diagnostic yield; ct-guided; drill system |
| Journal Title: | CardioVascular and Interventional Radiology |
| Volume: | 47 |
| Issue: | 1 |
| ISSN: | 0174-1551 |
| Publisher: | Springer |
| Date Published: | 2024-01-01 |
| Start Page: | 80 |
| End Page: | 86 |
| Language: | English |
| DOI: | 10.1007/s00270-023-03594-9 |
| PUBMED: | 37910259 |
| PROVIDER: | scopus |
| PMCID: | PMC11149476 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in PubMed and PDF -- Corresponding author is MSK author: Amgad M. Moussa -- Erratum issued, see DOI: [10.1007/s00270-023-03630-8] Source: Scopus |
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