Performance of intra-procedural 18-fluorodeoxyglucose PET/CT-guided biopsies for lesions suspected of malignancy but poorly visualized with other modalities Journal Article

   


Authors: Cornelis, F.; Silk, M.; Schoder, H.; Takaki, H.; Durack, J. C.; Erinjeri, J. P.; Sofocleous, C. T.; Siegelbaum, R. H.; Maybody, M.; Solomon, S. B.
Article Title: Performance of intra-procedural 18-fluorodeoxyglucose PET/CT-guided biopsies for lesions suspected of malignancy but poorly visualized with other modalities
Abstract: Purpose: We sought to evaluate the safety and the diagnostic success rate of percutaneous biopsies performed under intra-procedural 18 F-deoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT) guidance for lesions difficult to see with conventional cross-sectional imaging. Methods: From 2011 to 2013, consecutive clinically indicated percutaneous PET/CT-guided biopsies of 106 masses (mean size, 3.3 cm; range, 0.7–15.9 cm; SD, 2.9 cm) in bones (n = 33), liver (n = 26), soft tissues (n = 18), lung (n = 15) and abdomen (n = 14) were reviewed. The biopsy procedures were performed following injection of a mean of 255 MBq (SD, 74) FDG. Mean maximal standardized uptake value (SUV) of lesions was 8.8 (SD, 6.3). A systematic review of the histopathological results and outcomes was performed. Results: Biopsies were positive for malignancy in 76 cases (71.7 %, 76/106) and for benign tissue in 30 cases (28.3 %, 30/106). Immediate results were considered adequate for 100 PET/CT biopsies (94.3 %, 100/106) requiring no further exploration, and for the six others (5.7 %, 6/106) benign diagnoses were confirmed after surgery (n = 4) or follow-up (n = 2). The consequent overall sensitivity and the diagnostic success of biopsy were therefore 100 %. No significant differences in terms of detection of malignancy were observed between the different locations. Lesions > 2 cm or with SUV > 4 were not significantly more likely to be malignant. Complications occurred after four biopsies (3.7 %, 4/106). Conclusion: Intra-procedural PET/CT guidance appears as a safe and effective method and allows high diagnostic success of percutaneous biopsies for metabolically active lesions. © 2014, Springer-Verlag Berlin Heidelberg.
Keywords: adolescent; adult; child; aged; middle aged; positron emission tomography; radiopharmaceuticals; neoplasms; computer assisted tomography; tomography, x-ray computed; pathology; biopsy; liver; abdomen; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; bone; lung; predictive value of tests; radiopharmaceutical agent; scintiscanning; interventional radiology; bone and bones; predictive value; pet/ct; adverse effects; subcutaneous tissue; multimodal imaging; image guided biopsy; image-guided biopsy; cancer; humans; human; male; female; evaluation study; diagnostic use
Journal Title: European Journal of Nuclear Medicine and Molecular Imaging
Volume: 41
Issue: 12
ISSN: 1619-7070
Publisher: Springer  
Date Published: 2014-12-01
Start Page: 2265
End Page: 2272
Language: English
DOI: 10.1007/s00259-014-2852-1
PUBMED: 25106463
PROVIDER: scopus
PMCID: PMC6614874
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84938507913&partnerID=40&md5=cd12b60d01d555c01b9587f470a57bc6
Notes: Export Date: 2 September 2015 -- Source: Scopus
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MSK Authors
  1. Heiko Schoder
    550 Schoder
  2. Majid Maybody
    98 Maybody
  3. Robert H Siegelbaum
    21 Siegelbaum
  4. Stephen Solomon
    427 Solomon
  5. Joseph Patrick Erinjeri
    203 Erinjeri
  6. Constantinos T Sofocleous
    249 Sofocleous
  7. Jeremy Charles Durack
    116 Durack
  8. Mikhail Thomas Silk
    21 Silk
  9. Haruyuki Takaki
    7 Takaki
  10. Francois Henri Roger Cornelis
    81 Cornelis
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