Clinical value of (18)F-FDG-PET/CT in staging cutaneous squamous cell carcinoma Journal Article
| Authors: | Mahajan, S.; Barker, C. A.; Singh, B.; Pandit-Taskar, N. |
| Article Title: | Clinical value of (18)F-FDG-PET/CT in staging cutaneous squamous cell carcinoma |
| Abstract: | BackgroundCutaneous squamous cell carcinoma (cSCC) is the second most common skin malignancy. Computed tomography (CT) and/or MRI are commonly used for staging, however, the role of fluorine-18-fluorodeoxyglucose (18F-FDG)-PET is not clearly established. In this study, we evaluated 18F-FDG-PET/CT imaging for initial staging of cSCC.Patients and methods18F-FDG-PET/CT scans performed in patients with newly diagnosed cSCC were reviewed retrospectively. Images were visually assessed for lesions and 18F-FDG uptake [standardized uptake value (SUV)] in primary and secondary sites was measured. Suspected lesions on 18F-FDG-PET/CT were correlated with histopathology when available, follow-up imaging or clinical data in others.ResultsTwenty-three cSCC patients who underwent 18F-FDG-PET/CT at diagnosis were evaluated. Primary sites were in head/neck (n=21), chest (n=1), and foot (n=1). All patients had 18F-FDG-positive scans with a total of 51 18F-FDG-positive lesions. All primary lesions (n=24) were 18F-FDG-positive (SUV: 2.3-22.8; mean 10.2), and additional 27 18F-FDG-positive lesions, including 21 nodes, four cutaneous, one osseous and one lung lesion, were noted in 13 patients. Mean size of 18F-FDG-positive nodes was 0.9 cm (range: 0.4-2.5 cm), predominantly clinically impalpable. Pathology was available for 40/51 lesions; 31 sites positive for malignancy. SUV (mean±SD) was 9.2±6.2 for malignant and 2.7±1.2 for benign lesions. Sensitivity, positive predictive value, and accuracy of 18F-FDG-PET/CT scan were 100, 77.5, and 77.5%, respectively. 18F-FDG detected seven additional lesions in three patients, compared to CT/MRI. Overall, staging 18F-FDG-PET/CT detected nine prior unknown lesions in five patients that were proven metastatic disease by histopathology or follow-up; 18F-FDG-PET/CT modified management in 5/23 (21.7%) patients.Conclusion18F-FDG-PET/CT has high sensitivity in the detection of cSCC lesions, including small cutaneous and nodal disease, and has a potential role in initial staging and management. © 2019 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | squamous cell carcinoma; staging; lymphatic metastasis; neoplasm; neoplasms; skin; cutaneous; pet; fluorine-18-fluorodeoxyglucose |
| Journal Title: | Nuclear Medicine Communications |
| Volume: | 40 |
| Issue: | 7 |
| ISSN: | 0143-3636 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2019-07-01 |
| Start Page: | 744 |
| End Page: | 751 |
| Language: | English |
| DOI: | 10.1097/mnm.0000000000001029 |
| PUBMED: | 31095044 |
| PROVIDER: | scopus |
| PMCID: | PMC7518232 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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342Pandit-Taskar -
20Mahajan
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