Features of benign nonmelanocytic dermal and subcutaneous lesions on ex vivo confocal microscopy and histopathologic correlation Book Section
| Authors: | Farabi, B.; Harris, U.; Hartmann, D.; Rao, B. K.; Jain, M. |
| Editors: | Jain, M.; Rossi, A.; Nehal, K.; Sendín-Martín, M. |
| Article/Chapter Title: | Features of benign nonmelanocytic dermal and subcutaneous lesions on ex vivo confocal microscopy and histopathologic correlation |
| Abstract: | Benign nonmelanocytic dermal and subcutaneous lesions can have vascular (hemangioma, angiokeratoma, pyogenic granuloma), neural (neuroma, neurofibroma, schwannoma), fibrous (dermatofibroma, acrochordon), adnexal (sebaceous hyperplasia), or mesenchymal (lipoma, angiolipoma) origin. Although benign in nature, these lesions often clinically mimic malignant lesions such as BCC or other adnexal tumors, requiring biopsy for histopathology confirmation. Histopathology is the gold standard but requires tissue processing that delays diagnosis and management of the lesions. Reflectance confocal microscopy (RCM) can readily image some of these lesions that are located in the superficial dermis including hemangioma, sebaceous hyperplasia, and dermatofibroma; however, its role is limited for visualization of the deeper lesions such as lipoma and neurofibroma due to limited depth of imaging (~200 microns). Ex vivo confocal microscopy (EVCM) allows rapid evaluation of freshly excised tissues from various organ systems (e.g., esophagus, trachea, lung, breast tissues, and skin) and is being explored as an alternative to a frozen section or during grossing surgical specimens . EVCM could be useful to diagnose these deeper benign lesions such as lipoma and neurofibroma at the bedside, aiding in immediate management and alleviating patient’s anxiety. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022. |
| Keywords: | dermatofibroma; neurofibroma; lipoma; fibroepithelial polyp; histopathologic correlation; fluorescence confocal microscopy; ex vivo confocal microscopy; digital h&e; intraepidermal cyst |
| Book Title: | Cutaneous Atlas of Ex Vivo Confocal Microscopy |
| ISBN: | 978-3-030-89315-6 |
| Publisher: | Springer Nature |
| Publication Place: | Cham, Switzerland |
| Date Published: | 2022-01-01 |
| Start Page: | 67 |
| End Page: | 77 |
| Language: | English |
| DOI: | 10.1007/978-3-030-89316-3_6 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 6 -- Located in "Part III: Benign Skin Tumours" -- Source: Scopus |
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