Concurrent chemotherapy and radiotherapy for head and neck cancer Journal Article
| Authors: | Burri, R. J.; Lee, N. Y. |
| Article Title: | Concurrent chemotherapy and radiotherapy for head and neck cancer |
| Abstract: | Head and neck cancer is best managed in a multidisciplinary setting. Surgery, radiation therapy, chemotherapy and, more recently, biologic therapy are often employed in various combinations in an attempt to eradicate both clinically apparent and occult disease. The goals of treatment include maximizing tumor control while maintaining function and quality of life. Most patients present with locally advanced disease, and multimodality organ-conserving therapy is often employed for these patients based on the results of multiple Phase III clinical trials. This article focuses on the rationale and evidence supporting the use of concurrent chemotherapy and radiation therapy in the management of locally advanced head and neck cancers. © 2009 Expert Reviews Ltd. |
| Keywords: | cancer survival; treatment outcome; treatment response; cancer surgery; overall survival; clinical trial; drug tolerability; review; laryngectomy; squamous cell carcinoma; carcinoma, squamous cell; bevacizumab; cisplatin; fluorouracil; cancer combination chemotherapy; drug efficacy; multimodality cancer therapy; clinical trials as topic; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; disease free survival; chemotherapy, adjuvant; radiotherapy, adjuvant; chemotherapy; cancer staging; carboplatin; low drug dose; progression free survival; quality of life; multiple cycle treatment; continuous infusion; cetuximab; docetaxel; survival time; add on therapy; head and neck cancer; head and neck neoplasms; radiation dose fractionation; intermethod comparison; altered fractionation; biologic therapy; organ preservation; radiation therapy; nasopharynx carcinoma; meta-analysis as topic |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 9 |
| Issue: | 3 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2009-03-01 |
| Start Page: | 293 |
| End Page: | 302 |
| Language: | English |
| DOI: | 10.1586/14737140.9.3.293 |
| PUBMED: | 19275508 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: ERATB" - "Source: Scopus" |
