Cancer of the head and neck Book Section
| Authors: | Leeman, J. E.; Katabi, N.; Wong, R. J.; Lee, N. Y.; Romesser, P. B. |
| Editors: | Niederhuber, J. E.; Armitage, J. O.; Kastan, M. B.; Doroshow, J. H.; Tepper, J. E. |
| Article/Chapter Title: | Cancer of the head and neck |
| Abstract: | In the United States it is estimated that there will be 51, 540 new cases of head and neck cancer in 2018, accounting for 3% of all cancer cases and 1.5% of all cancer deaths. The three major risk factors for head and neck cancer are tobacco, human papillomavirus (HPV) infection, and alcohol. The treatment of head and neck cancer is dictated by the primary site. Most oropharyngeal cancers in the United States are now due to human papillomavirus (HPV) and as such have an improved prognosis. Early-stage oropharynx cancers can effectively be treated with surgery or RT. The standard of care for locally advanced disease is CRT; however, incorporation of transoral robotic surgery (TORS) is under active investigation. Surgery is generally considered the preferred initial treatment modality for oral cavity lesions with adjuvant RT with or without chemotherapy for patients with high-risk features on surgical pathology. In patients with laryngeal cancer, the goal of first-line therapy should be to preserve the function of the larynx, without sacrificing tumor control. Early-stage laryngeal cancer can effectively be treated with either surgery or RT. In early stage disease, the anatomic location and extent of disease will dictate if surgery is feasible. The treatment of choice in most locally advanced larynx cancers is concurrent chemotherapy and radiation. Management of head and neck cancers requires a multidisciplinary approach with effective integration of multiple specialties to achieve the desired goals of cure and functional organ preservation. © 2020 Elsevier Inc. |
| Book Title: | Abeloff’s Clinical Oncology. 6th ed |
| ISBN: | 9780323476744 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Philadelphia, PA |
| Date Published: | 2020-01-01 |
| Start Page: | 999 |
| End Page: | 1033.e7 |
| Language: | English |
| DOI: | 10.1016/b978-0-323-47674-4.00065-7 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 65, part of "Section B: Head, Neck, and Eye" in "Part III: Specific Malignancies" -- Export Date: 1 March 2022 -- Source: Scopus |
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