The role of radiation, immunotherapy, and chemotherapy in the management of locally advanced or metastatic cutaneous malignancies Review

   


Authors: Yacoub, I.; Rayn, K.; Choi, J. I.; Bakst, R.; Chhabra, A.; Qian, J. Y.; Johnstone, P.; Simone, C. B. 2nd
Review Title: The role of radiation, immunotherapy, and chemotherapy in the management of locally advanced or metastatic cutaneous malignancies
Abstract: Introduction: Skin cancer impacts a significant proportion of the population. While surgical management is often the mainstay of treatment, advanced or metastatic cutaneous malignancies require additional local and/or systemic therapies. Methods: A review of the literature was performed studying the use of radiation therapy, chemotherapy, and immunotherapy for locally advanced or metastatic cutaneous malignancies. Results: A summary of the present literature on the management of locally advanced or metastatic cutaneous malignancies is presented across cutaneous head and neck basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The addition of multidisciplinary therapies to resection is often associated with improved outcomes. Conclusion: The management of cutaneous head and neck malignancies requires an approach integrating multiple specialties, to optimize outcomes and minimize toxicities. © 2024 by the authors.
Keywords: review; squamous cell carcinoma; systemic therapy; melanoma; metastasis; radiotherapy; basal cell; immunotherapy; head and neck cancer; cutaneous; surgery; merkel cell carcinoma; drug therapy; therapy; squamous cell; merkel cell; human; male; special situation for pharmacovigilance; head and neck basal cell carcinoma
Journal Title: Cancers
Volume: 16
Issue: 23
ISSN: 2072-6694
Publisher: MDPI  
Date Published: 2024-12-01
Start Page: 3920
Language: English
DOI: 10.3390/cancers16233920
PROVIDER: scopus
PMCID: PMC11640331
PUBMED: 39682109
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85212143799&doi=10.3390%2fcancers16233920&partnerID=40&md5=5eaa8d112e5b1ab40d9ee92b9ebd9bd9
Notes: Review -- MSK corresponding author is Charles B. Simone 2nd -- Source: Scopus
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MSK Authors
  1. Charles Brian Simone
    190 Simone
  2. Jehee Isabelle Choi
    70 Choi
  3. Joshua Yuan Qian
    6 Qian
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