Radiation therapy and management of the cervical lymph nodes and malignant skull base tumors Book Section
| Authors: | Grégoire, V.; Lee, N.; Hamoir, M.; Yu, Y. |
| Editors: | Flint, P. W.; Francis, H. W.; Haughey, B. H.; Lesperance, M .M.; Lund, V. J.; Robbins, K. T. |
| Article/Chapter Title: | Radiation therapy and management of the cervical lymph nodes and malignant skull base tumors |
| Abstract: | This chapter discusses the management of the neck by surgery, (chemo)-radiation or both for node-negative and the node-positive patients as well as the management of malignant anterior and middle skull base tumors. Node-negative patients with mucosal squamous cell carcinoma of the head and neck region can be treated either by surgery or radiation; node-positive patients require a combined approach consisting of (chemo)-radiation with neck node dissection in case of residual disease, or neck node dissection with postoperative (chemo)-radiation. The choice between these options often depends on the management of the primary tumor and the expected morbidity. The complex anatomy of the skull base region requires a multidisciplinary approach to skull base neoplasms. Definitive surgical resection with or without postoperative radiotherapy is, in general, the favored treatment approach, with the notable exception of nasopharyngeal carcinoma treated with combined chemo- and radiotherapy. Because of the complex anatomy and the various radiosensitive normal structures, the use of advanced radiation delivery with intensity-modulated radiation therapy (IMRT), stereotactic treatment, or proton therapy is required. Because of the complexity of the disease and the intricacy with the complex anatomy, such patients should be managed in an expert cancer center. For both topics, this chapter discusses the physiopathologic background, the technical aspects, the expected outcome, and the morbidity encountered by modern multidisciplinary treatments. © 2021 Elsevier Inc. All rights reserved. |
| Keywords: | nasopharyngeal carcinoma; esthesioneuroblastoma; target volume delineation; neck node dissection; neck node levels; target volume selection |
| Book Title: | Cummings Otolaryngology: Head and Neck Surgery. 7th ed |
| Volume: | 1-3 |
| ISBN: | 978-0-323-61179-4 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Philadelphia, PA |
| Date Published: | 2021-01-01 |
| Start Page: | 1786 |
| End Page: | 1805.e6 |
| Language: | English |
| DOI: | 10.1016/b978-0-323-61179-4.00117-4 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book chapter: 117 -- Source: Scopus |
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