Biopathology of childhood, adolescent and young adult non-Hodgkin lymphoma Review
| Authors: | Lim, M. S.; Foley, M.; Mussolin, L.; Siebert, R.; Turner, S. |
| Review Title: | Biopathology of childhood, adolescent and young adult non-Hodgkin lymphoma |
| Abstract: | Mature non-Hodgkin lymphomas (NHL) in the childhood, adolescent and young adult (CAYA) population are rare and exhibit unique clinical, immunophenotypic and genetic characteristics. Application of large-scale unbiased genomic and proteomic technologies such as gene expression profiling and next generation sequencing (NGS) have led to enhanced understanding of the genetic basis for many lymphomas in adults. However, studies to investigate the pathogenetic events in CAYA population are relatively sparse. Enhanced understanding of the pathobiologic mechanisms involved in non-Hodgkin lymphomas in this unique population will allow for improved recognition of these rare lymphomas. Elucidation of the pathobiologic differences between CAYA and adult lymphomas will also lead to the design of more rational and much needed, less toxic therapies for this population. In this review, we summarize recent insights gained from the proceedings of the recent 7th International CAYA NHL Symposium held in New York City, New York October 20–23, 2022. © 2023 |
| Keywords: | adolescent; adult; child; young adult; review; biological marker; gene expression profiling; proteomics; risk assessment; chromosome aberration; b cell lymphoma; peripheral t cell lymphoma; t cell lymphoma; nonhodgkin lymphoma; lymphoma, non-hodgkin; cd4+ t lymphocyte; genomics; lymphoproliferative disease; large cell lymphoma; childhood; mycosis fungoides; burkitt lymphoma; chromosome 11q; primary mediastinal large b-cell lymphoma; non-hodgkin lymphoma; nk t cell lymphoma; genetic; hepatosplenic t cell lymphoma; anaplastic large cell lymphoma; diffuse large b cell lymphoma; angioimmunoblastic t cell lymphoma; humans; human; adolescent and young adult; nodal marginal zone lymphoma; pathobiology; subcutaneous t cell lymphoma; high grade b cell lymphoma; mediastinal lymphoma; cutaneous gamma delta t cell lymphoma; cytotoxic t lymphocyte lymphoma; hydroa vacciniforme like t cell lymphoma; mediastinal grey zone lymphoma; pediatric type follicular lymphoma |
| Journal Title: | Best Practice and Research: Clinical Haematology |
| Volume: | 36 |
| Issue: | 1 |
| ISSN: | 1521-6926 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-03-01 |
| Start Page: | 101447 |
| Language: | English |
| DOI: | 10.1016/j.beha.2023.101447 |
| PUBMED: | 36907637 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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