B-cell non-Hodgkin lymphomas Review
| Authors: | Silkenstedt, E.; Salles, G.; Campo, E.; Dreyling, M. |
| Review Title: | B-cell non-Hodgkin lymphomas |
| Abstract: | B-cell lymphomas occur with an incidence of 20 new cases per 100 000 people per year in high-income countries. They can affect any organ and are characterised by heterogeneous clinical presentations and courses, varying from asymptomatic, to indolent, to very aggressive cases. Since the topic of B-cell non-Hodgkin lymphomas was last reviewed in The Lancet in 2017, a deeper understanding of the biological background of this heterogeneous group of malignancies, the availability of new diagnostic methods, and the development and implementation of new targeted and immunotherapeutic approaches have improved our ability to treat patients. This Seminar provides an overview of the pathobiology, classification, and prognostication of B-cell non-Hodgkin lymphomas and summarises the current knowledge and standard of care regarding biology and clinical management of the most common subtypes of mature B-cell non-Hodgkin lymphomas. It also highlights new findings in deciphering the molecular background of disease development and the implementation of new therapeutic approaches, particularly those targeting the immune system. © 2024 Elsevier Ltd |
| Keywords: | adult; human tissue; middle aged; lenalidomide; prednisone; disease course; review; doxorubicin; ascites; pathophysiology; methotrexate; flow cytometry; bortezomib; mantle cell lymphoma; gene expression; incidence; cohort analysis; bendamustine; vincristine; hyperviscosity syndrome; waldenstroem macroglobulinemia; pathology; acute lymphoblastic leukemia; b cell lymphoma; lymphoma, b-cell; immunotherapy; biological activity; genomic instability; splenomegaly; pleura effusion; lactate dehydrogenase; autoimmune hemolytic anemia; monoclonal immunoglobulinemia; follicular lymphoma; lymphadenopathy; burkitt lymphoma; non-hodgkin lymphoma; hairy cell leukemia; common acute lymphoblastic leukemia antigen; notch2 receptor; cyclin dependent kinase 6; chemokine receptor cxcr4; cd23 antigen; acute myeloid leukemia; lymphocytosis; diffuse large b cell lymphoma; hemoglobin determination; excisional biopsy; angiofollicular lymph node hyperplasia; malt lymphoma; ibrutinib; stat6 protein; humans; prognosis; human; male; female; mucosa associated lymphoid tissue lymphoma translocation protein 1; obinutuzumab; testicular lymphoma; venetoclax; positron emission tomography-computed tomography; b cell chronic lymphocytic leukemia; cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine; acalabrutinib |
| Journal Title: | Lancet |
| Volume: | 403 |
| Issue: | 10438 |
| ISSN: | 0140-6736 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2024-05-04 |
| Start Page: | 1791 |
| End Page: | 1807 |
| Language: | English |
| DOI: | 10.1016/s0140-6736(23)02705-8 |
| PUBMED: | 38614113 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF -- Source: Scopus |
