Peripheral T-cell lymphoma – Are we making progress? Journal Article

   


Authors: Khan, N.; Ozkaya, N.; Moskowitz, A.; Dogan, A.; Horwitz, S.
Article Title: Peripheral T-cell lymphoma – Are we making progress?
Abstract: Peripheral T cell lymphoma (PTCL) is a rare subtype of non-Hodgkin lymphoma. PTCLs are heterogeneous in terms of biology, but generally have more aggressive features and poorer outcomes than aggressive B-cell lymphomas when treated with combination chemotherapy. While the best long-term results are still seen with intensive chemotherapeutic approaches, significant progress has been made with molecular profiling identifying genetic drivers of PTCL that could serve as therapeutic targets. Tailoring therapy to different subtypes of PTCL may lead to more individualized approaches with the hope of improved outcomes. In this paper, we review current therapies for treatment of PTCL, newly identified molecular markers, and the role of emerging therapy and novel combinations of existing agents. © 2018 Elsevier Ltd
Keywords: review; cancer recurrence; cancer combination chemotherapy; cancer patient; t lymphocyte; cancer immunotherapy; gene expression; gene expression profiling; molecular marker; peripheral t cell lymphoma; t cell lymphoma; immunotherapy; lymphoma; romidepsin; pralatrexate; belinostat; t-cell; peripheral; anaplastic large cell lymphoma; angioimmunoblastic t cell lymphoma; brentuximab vedotin; human; priority journal; cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine
Journal Title: Best Practice and Research: Clinical Haematology
Volume: 31
Issue: 3
ISSN: 1521-6926
Publisher: Elsevier Inc.  
Date Published: 2018-09-01
Start Page: 306
End Page: 314
Language: English
DOI: 10.1016/j.beha.2018.07.010
PROVIDER: scopus
PUBMED: 30213401
PMCID: PMC8941989
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050349989&doi=10.1016%2fj.beha.2018.07.010&partnerID=40&md5=e8d9c45d8b29a4132319cc3dc4e3825d
Notes: Review -- Export Date: 1 October 2018 -- Source: Scopus
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MSK Authors
  1. Steven M Horwitz
    645 Horwitz
  2. Alison Moskowitz
    339 Moskowitz
  3. Ahmet Dogan
    454 Dogan
  4. Niloufer Khan
    48 Khan
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