Reproducibility of T1ρ and T2 quantification in a multi-vendor multi-site study Journal Article


Authors: Lartey, R.; Nanavati, A.; Kim, J.; Li, M.; Xu, K.; Nakamura, K.; Shin, W.; Winalski, C. S.; Obuchowski, N.; Bahroos, E.; Link, T. M.; Hardy, P. A.; Peng, Q.; Liu, K.; Fung, M.; Wu, C.; Li, X.
Article Title: Reproducibility of T1ρ and T2 quantification in a multi-vendor multi-site study
Abstract: Objective: To evaluate the multi-vendor multi-site reproducibility of two-dimensional (2D) multi-echo spin-echo (MESE) T2 mapping (product sequences); and to evaluate the longitudinal reproducibility of three-dimensional (3D) magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshots (MAPSS) T1ρ and T2 mapping (research sequences), and 2D MESE T2 mapping, separated by 6 months, in a multi-vendor multi-site setting. Methods: Phantoms and volunteers (n = 5 from each site, n = 20 in total) were scanned on four 3 T magnetic resonance (MR) systems from four sites and three vendors (Siemens, General Electric, and Phillips). Two traveling volunteers (3 knees) scanned at all 4 sites at baseline and 6-month follow-up. Data was transferred to one site for centralized processing. Coefficients of variation (CVs) were calculated to evaluate reproducibility. Results: For baseline 2D MESE T2 measures, average CV were 0.37–2.45% (intra-site) and 5.96% (inter-site) for phantoms, and 3.15–8.49% (intra-site) and 14.16% (inter-site) for volunteers. For longitudinal phantom data, intra-site CVs were 1.42–3.48% for 3D MAPSS T1ρ, 1.77–3.56% for 3D MAPSS T2, and 1.02–2.54% for 2D MESE T2. For the longitudinal volunteer data, the intra-site CVs were 2.60–4.86% for 3D MAPSS T1ρ, 3.33–7.25% for 3D MAPSS T2, and 3.11–8.77% for 2D MESE T2. Conclusion: This study demonstrated excellent intra-site reproducibility of 2D MESE T2 imaging, while its inter-site variation was slightly higher than 3D MAPSS T2 imaging (10.06% as previously reported). This study also showed excellent reproducibility of longitudinal T1ρ and T2 cartilage quantification, in a multi-vendor multi-site setting for both product 2D MESE T2 and 3D MAPSS T1p/T2 research sequences. © 2022 Osteoarthritis Research Society International
Keywords: controlled study; nuclear magnetic resonance imaging; follow up; magnetic resonance imaging; reproducibility; reproducibility of results; intermethod comparison; phantoms, imaging; mathematical computing; volunteer; normal human; longitudinal study; knee radiography; human experiment; repeatability; procedures; knee meniscus; data processing; articular cartilage; three-dimensional imaging; imaging phantom; humans; human; article; t2; cartilage, articular; two-dimensional imaging; t1ρ; cartilage imaging; three-dimensional magnetization-prepared angle-modulated partitioned k-space spoiled gradient echo snapshot; two-dimensional multi-echo spin-echo
Journal Title: Osteoarthritis and Cartilage
Volume: 31
Issue: 2
ISSN: 1063-4584
Publisher: Elsevier Science, Inc.  
Date Published: 2023-02-01
Start Page: 249
End Page: 257
Language: English
DOI: 10.1016/j.joca.2022.10.017
PUBMED: 36370959
PROVIDER: scopus
PMCID: PMC10016129
DOI/URL:
Notes: Article -- Export Date: 1 March 2023 -- Source: Scopus
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
  1. Can Wu
    19 Wu