Novel super-resolution approach to time-resolved volumetric 4-dimensional magnetic resonance imaging with high spatiotemporal resolution for multi-breathing cycle motion assessment Journal Article


Authors: Li, G.; Wei, J.; Kadbi, M.; Moody, J.; Sun, A.; Zhang, S.; Markova, S.; Zakian, K.; Hunt, M.; Deasy, J. O.
Article Title: Novel super-resolution approach to time-resolved volumetric 4-dimensional magnetic resonance imaging with high spatiotemporal resolution for multi-breathing cycle motion assessment
Abstract: Purpose To develop and evaluate a super-resolution approach to reconstruct time-resolved 4-dimensional magnetic resonance imaging (TR-4DMRI) with a high spatiotemporal resolution for multi-breathing cycle motion assessment. Methods and Materials A super-resolution approach was developed to combine fast 3-dimensional (3D) cine MRI with low resolution during free breathing (FB) and high-resolution 3D static MRI during breath hold (BH) using deformable image registration. A T1-weighted, turbo field echo sequence, coronal 3D cine acquisition, partial Fourier approximation, and SENSitivity Encoding parallel acceleration were used. The same MRI pulse sequence, field of view, and acceleration techniques were applied in both FB and BH acquisitions; the intensity-based Demons deformable image registration method was used. Under an institutional review board–approved protocol, 7 volunteers were studied with 3D cine FB scan (voxel size: 5 × 5 × 5 mm3) at 2 Hz for 40 seconds and a 3D static BH scan (2 × 2 × 2 mm3). To examine the image fidelity of 3D cine and super-resolution TR-4DMRI, a mobile gel phantom with multi-internal targets was scanned at 3 speeds and compared with the 3D static image. Image similarity among 3D cine, 4DMRI, and 3D static was evaluated visually using difference image and quantitatively using voxel intensity correlation and Dice index (phantom only). Multi-breathing-cycle waveforms were extracted and compared in both phantom and volunteer images using the 3D cine as the references. Results Mild imaging artifacts were found in the 3D cine and TR-4DMRI of the mobile gel phantom with a Dice index of >0.95. Among 7 volunteers, the super-resolution TR-4DMRI yielded high voxel-intensity correlation (0.92 ± 0.05) and low voxel-intensity difference (<0.05). The detected motion differences between TR-4DMRI and 3D cine were −0.2 ± 0.5 mm (phantom) and −0.2 ± 1.9 mm (diaphragms). Conclusion Super-resolution TR-4DMRI has been reconstructed with adequate temporal (2 Hz) and spatial (2 × 2 × 2 mm3) resolutions. Further TR-4DMRI characterization and improvement are necessary before clinical applications. Multi-breathing cycles can be examined, providing patient-specific breathing irregularities and motion statistics for future 4D radiation therapy. © 2017 Elsevier Inc.
Keywords: magnetic resonance imaging; patient treatment; image processing; clinical application; image registration; deformation; acceleration technique; optical resolving power; deformable image registration; methods and materials; institutional review boards; sensitivity encoding; spatio-temporal resolution; voxel intensities
Journal Title: International Journal of Radiation Oncology, Biology, Physics
Volume: 98
Issue: 2
ISSN: 0360-3016
Publisher: Elsevier Inc.  
Date Published: 2017-06-01
Start Page: 454
End Page: 462
Language: English
DOI: 10.1016/j.ijrobp.2017.02.016
PROVIDER: scopus
PUBMED: 28463165
PMCID: PMC5481849
DOI/URL:
Notes: Conference Paper -- Export Date: 2 June 2017 -- Source: Scopus
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MSK Authors
  1. Guang Li
    54 Li
  2. Kristen L Zakian
    74 Zakian
  3. Joseph Owen Deasy
    279 Deasy
  4. Margie A Hunt
    229 Hunt
  5. Shirong Zhang
    4 Zhang
  6. Jason Frank Moody
    5 Moody
  7. August Gaoquan Sun
    4 Sun