Multisite MRI intravoxel incoherent motion repeatability and reproducibility across 3 T scanners in a breast diffusion phantom: A BReast Intravoxel Incoherent Motion Multisite (BRIMM) study Journal Article

   

Authors:	Basukala, D.; Mikheev, A.; Sevilimedu, V.; Gilani, N.; Moy, L.; Pinker, K.; Thakur, S. B.; Sigmund, E. E.
Article Title:	Multisite MRI intravoxel incoherent motion repeatability and reproducibility across 3 T scanners in a breast diffusion phantom: A BReast Intravoxel Incoherent Motion Multisite (BRIMM) study
Abstract:	Background: Monoexponential apparent diffusion coefficient (ADC) and biexponential intravoxel incoherent motion (IVIM) analysis of diffusion-weighted imaging is helpful in the characterization of breast tumors. However, repeatability/reproducibility studies across scanners and across sites are scarce. Purpose: To evaluate the repeatability and reproducibility of ADC and IVIM parameters (tissue diffusivity (Dt), perfusion fraction (Fp) and pseudo-diffusion (Dp)) within and across sites employing MRI scanners from different vendors utilizing 16-channel breast array coils in a breast diffusion phantom. Study Type: Phantom repeatability. Phantom: A breast phantom containing tubes of different polyvinylpyrrolidone (PVP) concentrations, water, fat, and sponge flow chambers, together with an MR-compatible liquid crystal (LC) thermometer. Field Strength/Sequence: Bipolar gradient twice-refocused spin echo sequence and monopolar gradient single spin echo sequence at 3 T. Assessment: Studies were performed twice in each of two scanners, located at different sites, on each of 2 days, resulting in four studies per scanner. ADCs of the PVP and water were normalized to the vendor-provided calibrated values at the temperature indicated by the LC thermometer for repeatability/reproducibility comparisons. Statistical Tests: ADC and IVIM repeatability and reproducibility within and across sites were estimated via the within-system coefficient of variation (wCV). Pearson correlation coefficient (r) was also computed between IVIM metrics and flow speed. A P value <0.05 was considered statistically significant. Results: ADC and Dt demonstrated excellent repeatability (<2%; <3%, respectively) and reproducibility (both <5%) at the two sites. Fp and Dp exhibited good repeatability (mean of two sites 3.67% and 5.59%, respectively) and moderate reproducibility (mean of two sites 15.96% and 13.3%, respectively). The mean intersite reproducibility (%) of Fp/Dp/Dt was 50.96/13.68/5.59, respectively. Fp and Dt demonstrated high correlations with flow speed while Dp showed lower correlations. Fp correlations with flow speed were significant at both sites. Data Conclusion: IVIM reproducibility results were promising and similar to ADC, particularly for Dt. The results were reproducible within both sites, and a progressive trend toward reproducibility across sites except for Fp. Level of Evidence: 2. Technical Efficacy: Stage 1. © 2023 International Society for Magnetic Resonance in Medicine.
Keywords:	nuclear magnetic resonance imaging; reproducibility; reproducibility of results; breast cancer; image interpretation, computer-assisted; breast; diffusion; calibration; diagnostic imaging; breast neoplasms; computer assisted diagnosis; breast tumor; clinical effectiveness; phantoms, imaging; image processing, computer-assisted; image processing; motion; diffusion weighted imaging; diffusion magnetic resonance imaging; flow rate; repeatability; devices; procedures; apparent diffusion coefficient; humans; human; female; article; povidone; intravoxel incoherent motion imaging; breast phantom
Journal Title:	Journal of Magnetic Resonance Imaging
Volume:	59
Issue:	6
ISSN:	1053-1807
Publisher:	Wiley Blackwell
Date Published:	2024-06-01
Start Page:	2226
End Page:	2237
Language:	English
DOI:	10.1002/jmri.29008
PUBMED:	37702382
PROVIDER:	scopus
PMCID:	PMC10932866
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85170667461&doi=10.1002%2fjmri.29008&partnerID=40&md5=e130f15ea9cbd87e8d7216288ba7e347
Notes:	Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/216436