Novel spin-lock time sampling strategies for improved reproducibility in quantitative T1ρ mapping Journal Article
| Authors: | Jogi, S. P.; Peng, Q.; Jafari, R.; Otazo, R.; Wu, C. |
| Article Title: | Novel spin-lock time sampling strategies for improved reproducibility in quantitative T1ρ mapping |
| Abstract: | This study aimed to optimize the sampling of spin-lock times (TSLs) in quantitative T1ρ mapping for improved reproducibility. Two new TSL sampling schemes were proposed: (i) reproducibility-guided random sampling (RRS) and (ii) reproducibility-guided optimal sampling (ROS). They were compared to the existing linear sampling (LS) and precision-guided sampling (PS) schemes for T1ρ reproducibility through numerical simulations, phantom experiments, and volunteer studies. Each study evaluated the four sampling schemes with three commonly used T1ρ preparations based on composite and balanced spin-locking. Additionally, the phantom and volunteer studies investigated the impact of B0 and B1 field inhomogeneities on T1ρ reproducibility, respectively. The reproducibility was assessed using the coefficient of variation (CoV) by repeating the T1ρ measurements eight times for phantom experiments and five times for volunteer studies. Numerical simulations resulted in lower mean CoVs for the proposed RRS (1.74%) and ROS (0.68%) compared to LS (2.93%) and PS (3.68%). In the phantom study, the mean CoVs were also lower for RRS (2.7%) and ROS (2.6%) compared to LS (4.1%) and PS (3.1%). Furthermore, the mean CoVs of the proposed RRS and ROS were statistically lower (P < 0.001) compared to existing LS and PS schemes at a B1 offset of 20%. In the volunteer study, consistently lower mean CoVs were observed in bilateral thigh muscles for RRS (9.3%) and ROS (9.2%) compared to LS (10.9%) and PS (10.2%), and the difference was more prominent at B0 offsets higher than 50 Hz. The proposed sampling schemes improve the reproducibility of quantitative T1ρ mapping by optimizing the selection of TSLs. This improvement is especially beneficial for longitudinal studies that track and monitor disease progression and treatment response. © 2024 John Wiley & Sons Ltd. |
| Keywords: | adult; controlled study; nuclear magnetic resonance imaging; magnetic resonance imaging; reproducibility; reproducibility of results; diagnostic procedure; time factors; simulation; quantitative analysis; intermethod comparison; artifact; computer simulation; phantoms, imaging; spin labels; disease control; artifacts; nuclear magnetic resonance; normal human; sampling; human experiment; magnetism; phantoms; optimal sampling; time factor; procedures; oscillation; electron spin resonance spectroscopy; random sampling; imaging phantom; dynamic contrast enhanced mri; humans; human; male; female; article; reproducibilities; quantitative mri; t1ρ; spin-lock; spin label; linear sampling; lock time; sampling schemes; spinlock; quantitative t1 mapping; reproducibility guided optimal sampling; reproducibility guided random sampling; thigh muscle |
| Journal Title: | NMR in Biomedicine |
| Volume: | 37 |
| Issue: | 12 |
| ISSN: | 0952-3480 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2024-12-01 |
| Start Page: | e5244 |
| Language: | English |
| DOI: | 10.1002/nbm.5244 |
| PUBMED: | 39152756 |
| PROVIDER: | scopus |
| PMCID: | PMC11612825 |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors are MSK author: Sandeep Panwar Jogi and Can Wu -- Source: Scopus |
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