Involvement of opioid receptor subtypes in rat feeding behavior Journal Article

  


Authors: Simone, D. A.; Bodnar, R. J.; Goldman, E. J.; Pasternak, G. W.
Article Title: Involvement of opioid receptor subtypes in rat feeding behavior
Abstract: The short-acting opiate antagonist naloxone decreases food intake in three models of ingestive behavior: free feeding, food-deprivation induced feeding and deoxyglucose-induced feeding. Twenty-four hours after administration, the long-acting, mu1 selective antagonist naloxonazine inhibits food intake to the same extent as naloxone in freely feeding and food-deprived rats, but not in animals treated with 2-deoxyglucose. These results indicate that 1) opiates modulate feeding through multiple opioid receptor mechanisms, one of which is the mu subtype, and 2) the feeding observed in various experimental paradigms are modulated by different receptor subtypes. Furthermore, these results illustrate the usefulness of naloxone in defining a behavior as opioid but point out its limitations in discriminating between opioid receptor subtypes. © 1985.
Keywords: dose response; drug efficacy; nonhuman; animal; biological model; animal experiment; feeding behavior; drug screening; food intake; psychological aspect; drug mechanism; drug response; rat; rats; food deprivation; receptors, opioid, mu; intravenous drug administration; naloxone; opiate receptor; naloxonazine; drug comparison; intraperitoneal drug administration; deoxyglucose; rats, inbred strains; receptors, opioid; male; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: Life Sciences
Volume: 36
Issue: 9
ISSN: 0024-3205
Publisher: Elsevier Inc.  
Date Published: 1985-03-04
Start Page: 829
End Page: 833
Language: English
DOI: 10.1016/0024-3205(85)90206-1
PROVIDER: scopus
PUBMED: 2983173
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0021921080&doi=10.1016%2f0024-3205%2885%2990206-1&partnerID=40&md5=b6d2629f2259a1d5808213065f6b20b3
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
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