Opioid receptor involvement in food deprivation-induced feeding: Evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats Journal Article
| Authors: | Hadjimarkou, M. M.; Singh, A.; Kandov, Y.; Israel, Y.; Pan, Y. X.; Rossi, G. C.; Pasternak, G. W.; Bodnar, R. J. |
| Article Title: | Opioid receptor involvement in food deprivation-induced feeding: Evaluation of selective antagonist and antisense oligodeoxynucleotide probe effects in mice and rats |
| Abstract: | Central administration of general and selective opioid receptor subtype antagonists in the rat has revealed a substantial role for μ, a moderate role for κ, and a minimal role for δ receptors in the mediation of deprivation-induced feeding. Antisense probes directed against the κ opioid receptor (KOP), nociceptin opioid receptor (NOP), and δ opioid receptor (DOP) genes in rats result in reductions similar to κ and δ antagonists, whereas antisense probes directed against the μ opioid receptor (MOP) gene produced modest reductions relative to μ antagonists, suggesting that isoforms of the MOP gene may mediate deprivation-induced feeding. Since these isoforms were initially identified in mice, the present study compared the effects of general and selective opioid receptor antagonists on deprivation-induced feeding in rats and mice and antisense probes directed against exons of the MOP, DOP, KOP, and NOP genes on deprivation-induced feeding in the mouse, Food-deprived (12 and 24 h) rats and mice displayed similar profiles of reductions in deprivation-induced feeding following general, μ, and κ opioid antagonists. In contrast, mice, but not rats, displayed reductions in deprivation-induced intake following δ antagonism as well as DOP antisense probes, suggesting a species-specific role for the δ receptor. Antisense probes directed against the KOP and NOP genes also reduced deprivation-induced intake in mice in a manner similar to κ antagonism. However, the significant reductions in deprivation - induced feeding following antisense probes directed against either exons 2, 4, 7, 8, or 13 of the MOP gene were modest compared with μ antagonism, suggesting a role for multiple A-mediated mechanisms. |
| Keywords: | controlled study; unclassified drug; exon; exons; dose response; nonhuman; mouse; animals; mice; animal model; body weight; feeding behavior; food intake; eating; rat; rats; rats, sprague-dawley; homeostasis; mu opiate receptor; food deprivation; receptors, opioid, mu; opiate receptor; beta funaltrexamine; naltrindole; naltrexone; oligonucleotides, antisense; microinjection; reduction; delta opiate receptor; opiate antagonist; receptors, opioid, delta; animal behavior; kappa opiate receptor; antisense oligodeoxynucleotide; narcotic antagonists; species comparison; receptors, opioid; male; priority journal; article; binaltorphimine; nociceptin opiate receptor; receptors, opioid, kappa |
| Journal Title: | Journal of Pharmacology and Experimental Therapeutics |
| Volume: | 311 |
| Issue: | 3 |
| ISSN: | 0022-3565 |
| Publisher: | American Society for Pharmacology and Experimental Therapeutics |
| Date Published: | 2004-12-01 |
| Start Page: | 1188 |
| End Page: | 1202 |
| Language: | English |
| DOI: | 10.1124/jpet.104.071761 |
| PROVIDER: | scopus |
| PUBMED: | 15333676 |
| DOI/URL: | |
| Notes: | J. Pharmacol. Exp. Ther. -- Cited By (since 1996):16 -- Export Date: 16 June 2014 -- CODEN: JPETA -- Source: Scopus |
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