Reduction by central ß-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions Journal Article
| Authors: | Arjune, D.; Standifer, K. M.; Pasternak, G. W.; Bodnar, R. J. |
| Article Title: | Reduction by central ß-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions |
| Abstract: | The present study evaluated the central effects of ß-funaltrexamine (B-FNA), a non-equilibrium antagonist of μ-opioid receptors and a reversible agonist of κ-opioid receptors upon food intake in rats under freely-feeding, deprivation and glucoprivic conditions. B-FNA elicited distinct short-term and long-term actions, consistent with binding studies demonstrating its reversible κ agonist actions and its irreversible μ receptor blockade. Whereas B-FNA (1-20 μg, i.c.v.) significantly stimulated free feeding for up to 6 h, B-FNA (10-20 μg) significantly inhibited (35-41%) free feeding at 24, 48 and 72 h after injection, a pattern temporally similar to its biochemical opioid effects. Pretreatment (24 h) with B-FNA (10-20 μg) significantly inhibited (33-49%) the increased intake following 24 h of food deprivation. Pretreatment (24 h) with B-FNA (10-20 μg) also significantly inhibited (75-100%) the increased glucoprivic intake induced by 2-deoxy-d-glucose. The short-term stimulation of food intake by central B-FNA was antagonized by the selective κ antagonist, nor-binaltorphamine, but was unaffected by pretreatment 24 h earlier with the μ antagonist, B-FNA. Significant reductions in striatal (89%) and hypothalamic (46%) μ-opioid binding occurred in rats pretreated (24 h) with B-FNA; the low levels of δ binding in these structures precluded interpretation of B-FNA effects. These data indicate the importance of the μ-opioid receptor in the modulation of different forms of feeding behavior, and underscores the ability of selective opioid antagonists to delineate precise functional roles for different opioid receptor subtypes. © 1990. |
| Keywords: | controlled study; nonhuman; animal; animal tissue; animal experiment; feeding behavior; dose-response relationship, drug; food intake; time factors; hypothalamus; rat; glucose; rats; mu opiate receptor; food deprivation; receptors, opioid, mu; receptor binding; corpus striatum; beta funaltrexamine; naltrexone; injections, intraventricular; receptors, opioid, delta; dietary carbohydrates; kappa opiate receptor; rats, inbred strains; narcotic antagonists; receptors, opioid; nor-binaltorphamine; norbinaltorphimine; male; priority journal; article; μ-opioid receptor; glucoprivation; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; ß-funaltrexamine; κ-opiod receptor |
| Journal Title: | Brain Research |
| Volume: | 535 |
| Issue: | 1 |
| ISSN: | 0006-8993 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 1990-12-03 |
| Start Page: | 101 |
| End Page: | 109 |
| Language: | English |
| DOI: | 10.1016/0006-8993(90)91828-5 |
| PUBMED: | 1963340 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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