The AIDS dementia complex: I. Clinical features Journal Article
| Authors: | Navia, B. A.; Jordan, B. D.; Price, R. W. |
| Article Title: | The AIDS dementia complex: I. Clinical features |
| Abstract: | Of 70 autopsied patients with the acquired immune deficiency syndrome (AIDS), 46 suffered progressive dementia that was frequently accompanied by motor and behavioral dysfunction. Impaired memory and concentration with psychomotor slowing represented the most common early presentation of this disorder, but in nearly one half of the patients either motor or behavioral changes predominated. Early motor deficits commonly included ataxia, leg weakness, tremor, and loss of fine‐motor coordination, while behavioral disturbances were manifested most commonly as apathy or withdrawal, but occasionally as a frank organic psychosis. The course of the disease was steadily progressive in most patients, and at times was punctuated by an abrupt acceleration. However, in 20% of patients a more protracted indolent course was observed. In the most advanced stage of this disease, patients exhibited a stereotyped picture of severe dementia, mutism, incontinence, paraplegia, and in some cases, myoclonus. The high incidence and unique clinical presentation of this AIDS dementia complex is consistent with the emerging concept that this complication is due to direct brain infection by the retrovirus that causes AIDS. Copyright © 1986 American Neurological Association |
| Keywords: | adult; clinical article; biology; incidence; tomography, x-ray computed; age factors; histology; central nervous system; physiology; psychological aspect; diagnosis; dementia; data analysis; measurement; mental disorders; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; behavior disorder; autopsy; motor dysfunction; diseases; hiv infections; human immunodeficiency virus 1; nervous system; studies; middle age; nervous system diseases; case studies; signs and symptoms; population characteristics; research methodology; human; male; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; viral diseases; blood and hemopoietic system; acquired immunodeficiency syndrome--complications; behavior--changes; central nervous system effects; neurologic effects; ophthalmological effects; population at risk; retinal effects |
| Journal Title: | Annals of Neurology |
| Volume: | 19 |
| Issue: | 6 |
| ISSN: | 0364-5134 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1986-06-01 |
| Start Page: | 517 |
| End Page: | 524 |
| Language: | English |
| DOI: | 10.1002/ana.410190602 |
| PUBMED: | 3729308 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: Dr. Godbold kindly advised us on statistical analysis. We thank Adele Ahronheim for preparation of this manuscript. |
