Sensory neuronopathy and small cell lung cancer: Antineuronal antibody that also reacts with the tumor Journal Article

  


Authors: Graus, F.; Elkon, K. B.; Cordon-Cardo, C.; Posner, J. B.
Article Title: Sensory neuronopathy and small cell lung cancer: Antineuronal antibody that also reacts with the tumor
Abstract: An autoantibody highly restricted to the nuclei of neurons was found in four patients with subacute sensory neuronopathy and small cell carcinoma of the lung. The antibody was not found in normal subjects or patients with or without cancer who did not have subacute sensory neuronopathy. One- and two-dimensional immunoblotting analysis of nuclear extracts of rat and human brain identified an antibody reactive with a 35-38 kilodalton (kd) basic nucleoprotein. An identical protein lacking the 38 kd peptide was identified in tumor extract of one of the patients. All four patients' serum reacted with the same antigen in the brain and the tumor. In the postmortem study of one of the patients, IgG was found within the neurons of the dorsal root ganglia by direct immunofluorescence. These findings support the hypothesis that the subacute sensory neuronopathy is caused by an antibody that cross-reacts with a tumor cell antigen and a brain nucleoprotein. © 1986.
Keywords: aged; case report; neuropathy; lung neoplasms; tumor antigen; central nervous system; immunoenzyme techniques; lung small cell cancer; fluorescent antibody technique; antibodies, monoclonal; antigens, neoplasm; immunoglobulin g; brain; diagnosis; autoantibody; neurons, afferent; serum; autoantibodies; carcinoma, small cell; nervous system; epitopes; middle age; nervous system diseases; respiratory system; cross reactions; sensation; human; male; female; priority journal; antibodies, antinuclear; support, u.s. gov't, p.h.s.; counterimmunoelectrophoresis
Journal Title: The American Journal of Medicine
Volume: 80
Issue: 1
ISSN: 0002-9343
Publisher: Elsevier Inc.  
Date Published: 1986-01-01
Start Page: 45
End Page: 52
Language: English
DOI: 10.1016/0002-9343(86)90047-1
PUBMED: 2417479
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022627256&doi=10.1016%2f0002-9343%2886%2990047-1&partnerID=40&md5=e8cc2dc38568f71e12b350221c96c94e
Notes: Article -- Export Date: 18 August 2021 -- Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Jerome B Posner
    211 Posner
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