Sera from some patients with antibody-associated paraneoplastic encephalomyelitis/sensory neuronopathy recognize the Ro-52K antigen Journal Article

  

Authors:	Manley, G.; Wong, E.; Dalmau, J.; Elkon, K.; Posner, J.; Furneaux, H.
Article Title:	Sera from some patients with antibody-associated paraneoplastic encephalomyelitis/sensory neuronopathy recognize the Ro-52K antigen
Abstract:	Screening a small cell lung cancer cDNA library with serum from a patient with antibody-associated paraneoplastic sensory neuronopathy (Anti-Hu syndrome) resulted in the isolation of a cDNA clone encoding the Ro-52 kD antigen. The Ro-52 kD antigen is one of the major antigens recognized by the sera of patients with Sjögren's syndrome and systemic lupus erythematosus. Further investigation revealed that the sera of only a small percentage (4%) of patients with the Hu syndrome reacted with Ro-52 kD antigen. The cross-reactivity may result from a domain of high homology between Ro-52 kD and the HuD antigen. These results emphasize the necessity of using recombinant antigens whenever possible when assaying for specific antibodies. © 1994 Kluwer Academic Publishers.
Keywords:	controlled study; sequence analysis; molecular cloning; cloning, molecular; rna-binding proteins; lung small cell cancer; blood; amino acid sequence; molecular sequence data; hybrid protein; recombinant fusion proteins; antigen recognition; epitope; autoantigens; ribonucleoproteins; base sequence; dna sequence; antibodies; sequence homology; cross reaction; paraneoplastic syndrome; molecular weight; serum; complementary dna; dna, complementary; encephalomyelitis; dna library; paraneoplastic syndromes; molecular probes; sensation disorders; sjoegren syndrome; paraneoplastic; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; ro-52 k; ribonucleoprotein antibody
Journal Title:	Journal of Neuro-Oncology
Volume:	19
Issue:	2
ISSN:	0167-594X
Publisher:	Springer
Date Published:	1994-06-01
Start Page:	105
End Page:	112
Language:	English
DOI:	10.1007/bf01306451
PROVIDER:	scopus
PUBMED:	7964985
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028058829&doi=10.1007%2fBF01306451&partnerID=40&md5=947dca079f3667cfb26e2ee05a715997
Notes:	J Neuro-Oncol -- Cited By :20 -- Export Date: 14 January 2019 -- Article -- CODEN: JNODD C2 - 7964985 -- Source: Scopus

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