Localized nodular synovitis mimicking metastatic melanoma in a patient with metastatic melanoma on whole-body F-18 FDG PET/CT with MRI and pathological correlation Journal Article
| Authors: | Mahmood, S.; De Llano, S. R. M. |
| Article Title: | Localized nodular synovitis mimicking metastatic melanoma in a patient with metastatic melanoma on whole-body F-18 FDG PET/CT with MRI and pathological correlation |
| Abstract: | A 47-year-old man with a history of malignant melanoma, status post wide local excision of the primary lesion of the left chest wall and postoperative interferon therapy for 1 week, presented with an indeterminate left upper lung lesion on CT. The patient was referred for an F-18 FDG-PET study to evaluate the extent of disease. PET/CT showed an intensely FDG avid nodule in the left upper lobe with a maximum standardized uptake value (SUVmax) of 6.9, and an incidental FDG avid lesion in the right mid leg, behind the right patella, with a SUVmax of 10.2, suggesting metastatic disease from malignant melanoma. Patient was referred for further characterization of this lesion with MRI. T1 and T2 MRI images demonstrated a hypointense mass in Hoffa's fat pad, caudal to the lower pole of the patella, posteriorly in contact with a minimal joint effusion suggesting localized pigmented villonodular synovitis (PVNS). This finding was subsequently confirmed on biopsy. The intense FDG activity in the subpatella lesion on FDG-PET in our case reminds us of the possibility of false-positive findings on FDG-PET in patients with malignant melanoma, and the usefulness of MRI in the evaluation of musculoskeletal lesions. © 2007 Lippincott Williams & Wilkins, Inc. |
| Keywords: | adult; human tissue; middle aged; cancer surgery; clinical feature; anamnesis; case report; interferon; nuclear magnetic resonance imaging; positron emission tomography; magnetic resonance imaging; radiopharmaceuticals; melanoma; statistics; image analysis; skin biopsy; diagnosis, differential; tomography, x-ray computed; diagnostic imaging; medical examination; whole body imaging; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; pet; false positive result; skin metastasis; musculoskeletal disease; mri; soft tissue neoplasms; synovitis; pigmented villonodular synovitis; whole body ct; knee joint; hoffa's fat pad; localized nodular synovitis; pvns |
| Journal Title: | Clinical Nuclear Medicine |
| Volume: | 32 |
| Issue: | 7 |
| ISSN: | 0363-9762 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2007-07-01 |
| Start Page: | 532 |
| End Page: | 534 |
| Language: | English |
| DOI: | 10.1097/RLU.0b013e3180646afb |
| PUBMED: | 17581337 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 17 November 2011" - "CODEN: CNMED" - "Source: Scopus" |
