Whole-body FDG-PET in patients with recurrent colorectal carcinoma. A comparative study with CT Journal Article
| Authors: | Imbriaco, M.; Akhurst, T.; Hilton, S.; Yeung, H. W. D.; Macapinlac, H. A.; Mazumdar, M.; Pace, L.; Kemeny, N.; Erdi, Y.; Cohen, A.; Fong, Y.; Guillem, J.; Larson, S. M. |
| Article Title: | Whole-body FDG-PET in patients with recurrent colorectal carcinoma. A comparative study with CT |
| Abstract: | Purpose: To assess the clinical accuracy of whole-body 2-[F-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) in the diagnosis of recurrent colorectal carcinoma in comparison to conventional computed tomography (CT). Materials and methods: Forty patients with suspected recurrent colorectal carcinoma based on either progressive serial carcinoemrbyonic antigen (CEA) serum elevation or positive/equivocal CT findings underwent whole-body FDG-PET. PET results were compared with those of CT and correlated to the final histopathological and clinical findings. Results: A final diagnosis was obtained at 93 sites in 35 patients by histology and in 5 patients by clinical follow up of at least 6 months. Of the 93 sites, 53 were determined to be malignant and 40 benign. FDG-PET evaluated on a 5-point scale (0-4) showed a positive and negative predictive value in the range of 96-98% and 83-93% respectively as the threshold for positivity was moved from 0 through 3. By comparison, CT, also evaluated on a 5-point scale showed a positive and negative predictive value in the range of 75-88%> and 67-71%> respectively. The area under the fitted receiver operating characteristic curve for PET: APET = 0.96 ± 0.02 was significantly greater (P < 0.001) than that observed for CT: ACT = 0.77 ± 0.06. The distribution of maximum standardized uptake value (SUVmax) showed that all negative lesions have SUVmax below 5.0 whereas 75% of positive lesions were above 5.0 pointing to the fact that disease positivity is more likely in lesions with high SUV values. Conclusion: The results of this study confirm that whole-body FDG-PET is more accurate than conventional CT in the staging of patients with suspected recurrent colorectal carcinoma. Copyright © 2000 Elsevier Science Inc. All rights reserved. |
| Keywords: | pet; ct; fdg; colon neoplasms |
| Journal Title: | Clinical Positron Imaging |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 1095-0397 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2000-05-01 |
| Start Page: | 107 |
| End Page: | 114 |
| Language: | English |
| DOI: | 10.1016/s1095-0397(00)00045-5 |
| PROVIDER: | scopus |
| PUBMED: | 11008100 |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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