Volume-based quantitative FDG PET/CT metrics and their association with optimal debulking and progression-free survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery Journal Article


Authors: Vargas, H. A.; Burger, I. A.; Goldman, D. A.; Miccò, M; Sosa, R. E.; Weber, W.; Chi, D. S.; Hricak, H.; Sala, E.
Article Title: Volume-based quantitative FDG PET/CT metrics and their association with optimal debulking and progression-free survival in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery
Abstract: Objective: Our aim was to evaluate the associations between quantitative 18 F-fluorodeoxyglucose positron-emission tomography (FDG-PET) uptake metrics, optimal debulking (OD) and progression-free survival (PFS) in patients with recurrent ovarian cancer undergoing secondary cytoreductive surgery. Methods: Fifty-five patients with recurrent ovarian cancer underwent FDG-PET/CT within 90 days prior to surgery. Standardized uptake values (SUVmax), metabolically active tumour volumes (MTV), and total lesion glycolysis (TLG) were measured on PET. Exact logistic regression, Kaplan-Meier curves and the log-rank test were used to assess associations between imaging metrics, OD and PFS. Results: MTV (p = 0.0025) and TLG (p = 0.0043) were associated with OD; however, there was no significant association between SUVmax and debulking status (p = 0.83). Patients with an MTV above 7.52 mL and/or a TLG above 35.94 g had significantly shorter PFS (p = 0.0191 for MTV and p = 0.0069 for TLG). SUVmax was not significantly related to PFS (p = 0.10). PFS estimates at 3.5 years after surgery were 0.42 for patients with an MTV ≤ 7.52 mL and 0.19 for patients with an MTV > 7.52 mL; 0.46 for patients with a TLG ≤ 35.94 g and 0.15 for patients with a TLG > 35.94 g. Conclusion: FDG-PET metrics that reflect metabolic tumour burden are associated with optimal secondary cytoreductive surgery and progression-free survival in patients with recurrent ovarian cancer. Key Points: • Both TLG and MTV were associated with optimal tumour debulking. • There was no significant association between SUVmaxand tumour debulking status. • Patients with higher MTV and/or TLG had significantly shorter PFS. • SUVmaxwas not significantly related to PFS. © 2015, European Society of Radiology.
Keywords: adult; cancer chemotherapy; treatment response; aged; cancer surgery; major clinical study; disease course; multimodality cancer therapy; outcome assessment; follow up; ovarian cancer; cytoreductive surgery; carboplatin; progression free survival; ovary cancer; tumor volume; recurrence; retrospective study; quantitative analysis; cancer size; fluorodeoxyglucose f 18; computer assisted emission tomography; imaging; pet/ct; secondary cytoreduction; human; female; priority journal; article; pet-ct scanner
Journal Title: European Radiology
Volume: 25
Issue: 11
ISSN: 0938-7994
Publisher: Springer  
Date Published: 2015-11-01
Start Page: 3348
End Page: 3353
Language: English
DOI: 10.1007/s00330-015-3729-9
PROVIDER: scopus
PMCID: PMC4596740
PUBMED: 25916387
DOI/URL:
Notes: Export Date: 2 November 2015 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Evis Sala
    95 Sala
  2. Dennis S Chi
    496 Chi
  3. Hedvig Hricak
    330 Hricak
  4. Debra Alyssa Goldman
    94 Goldman
  5. Irene Andrea Burger
    10 Burger
  6. Wolfgang Andreas Weber
    148 Weber
  7. Maura Micco
    10 Micco
  8. Ramon Elias Sosa
    16 Sosa