Prognostic significance of conventional and volumetric PET parameters with and without partial volume correction in the assessment of head and neck squamous cell carcinoma Journal Article
| Authors: | Zirakchian Zadeh, M.; Asadollahi, S.; Kaghazchi, F.; Raynor, W. Y.; Mehdizadeh Seraj, S.; Werner, T. J.; Seierstad, T.; Korostoff, J.; Swisher-Mcclure, S.; Alavi, A.; Revheim, M. E. |
| Article Title: | Prognostic significance of conventional and volumetric PET parameters with and without partial volume correction in the assessment of head and neck squamous cell carcinoma |
| Abstract: | Background The optimal quantification of PET in assessment of head and neck squamous cell carcinoma (HNSCC) is still under development. The effect of partial volume correction (PVC) on the evaluation of survival in the HNSCC patients has not been investigated yet. Methodology Pretreatment 18F-FDG-PET/CT scans of a selected group of 57 patients with advanced stage HNSCC were collected. Conventional (SUVmean and SUVmax) and volumetric [total lesion glycolysis (TLG) and metabolic tumor volume (MTV)] PET metrics were calculated. The ROVER software (ABX GmbH, Radeberg, Germany) automatically applied PVC to the PET metrics. Cox proportional hazards regression model calculated hazard ratio (HR) for assessment of predictive parameters of progression-free survival (PFS). Results In multivariate Cox regression analysis, including age, gender, race, human papillomavirus status, and stage, the only significant predictors of PFS were the volumetric PET parameters (TLG: HR, 1.003; 95% CI, 1.001-1.005; P = 0.02), pvcTLG (HR, 1.002; 95% CI, 1.001-1.004; P = 0.01) and MTV (HR, 1.050; 95% CI, 1.024-1.077; P < 0.01). The partial volume-corrected values were significantly higher than the noncorrected values (Wilcoxon sign test; P < 0.05). However, there was not a statistically significant difference between the nonpartial volume corrected and partial volume-corrected PET metrics for assessment of PFS. Conclusion Volumetric PET metrics were predictors of PFS in Cox regression analysis. Applying PVC could not significantly improve the accuracy of PET metrics for assessment of PFS. Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | retrospective studies; radiopharmaceuticals; tumor volume; diagnostic imaging; retrospective study; head and neck neoplasms; tumor burden; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; radiopharmaceutical agent; pet; head and neck tumor; head and neck squamous cell carcinoma; 18f-fdg; partial volume effect; polyvinylchloride; humans; prognosis; human; squamous cell carcinoma of head and neck; positron emission tomography-computed tomography; positron emission tomography computed tomography; pet/ct quantification; polyvinyl chloride |
| Journal Title: | Nuclear Medicine Communications |
| Volume: | 43 |
| Issue: | 7 |
| ISSN: | 0143-3636 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2022-07-01 |
| Start Page: | 800 |
| End Page: | 806 |
| Language: | English |
| DOI: | 10.1097/mnm.0000000000001573 |
| PUBMED: | 35552334 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 July 2022 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work