Paget disease of the humerus mimicking metastatic disease in a patient with metastatic malignant mesothelioma on whole body F-18 FDG PET/CT Journal Article
| Authors: | Mahmood, S.; Martinez De Llano, S. R. |
| Article Title: | Paget disease of the humerus mimicking metastatic disease in a patient with metastatic malignant mesothelioma on whole body F-18 FDG PET/CT |
| Abstract: | A 71-year-old man with newly diagnosed malignant mesothelioma was referred for an F-18 FDG PET/CT study to evaluate the extent of disease. PET showed mild FDG uptake in the right chest, corresponding to a lobulated, mass-like right pleural effusion versus thickening involving the entire right pleural space, and some mediastinal involvement, on the accompanying CT scan. In addition, marked FDG uptake was seen in the proximal left humerus, suspicious for an osseous metastasis. The corresponding CT scan findings of cortical thickening and a "Swiss cheese" appearance were most consistent with Paget disease. The intense FDG uptake in an osseous lesion on FDG-PET in our case reminds us of the variable nature of FDG uptake in Paget disease, the possibility of false-positive findings on FDG-PET in patients with cancer, and the usefulness of the fusion techniques in the evaluation of skeletal lesions, with the potential for discriminating between benign Paget disease and other pathologic bone findings. © 2008 by Lippincott Williams & Wilkins. |
| Keywords: | aged; bone neoplasms; bone tumor; humerus; case report; bone metastasis; positron emission tomography; methodology; radiopharmaceuticals; metastasis; computer assisted tomography; lung neoplasms; differential diagnosis; tomography, x-ray computed; pathology; lung tumor; fluorodeoxyglucose f 18; fluorodeoxyglucose f18; positron-emission tomography; neoplasm metastasis; radiopharmaceutical agent; scintiscanning; malignant mesothelioma; mesothelioma; pleura effusion; neoplasms, second primary; second cancer; pet; pet/ct; paget bone disease; paget's disease; osteitis deformans |
| Journal Title: | Clinical Nuclear Medicine |
| Volume: | 33 |
| Issue: | 7 |
| ISSN: | 0363-9762 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2008-07-01 |
| Start Page: | 510 |
| End Page: | 512 |
| Language: | English |
| DOI: | 10.1097/RLU.0b013e318177928a |
| PUBMED: | 18580246 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: CNMED" - "Source: Scopus" |
