| Abstract: |
The methodologies employed for the syntheses of C-nucleosides are categorized into four major classes: (1) by condensation of a heterocyclic base with a carbohydrate, (2) by construction of the heterocyclic moiety from a C-1 functionalized carbohydrate, (3) by total synthesis from simple, optically inactive molecules, and (4) by conversion of a preformed C-nucleoside into another C-nucleoside. Each category is discussed with representative synthetic examples with brief attention to biological and medical significance. © 1987, The Society of Synthetic Organic Chemistry, Japan. All rights reserved. |
