Nucleosides 137. Synthetic modifications at the 2′-position of pyrrolo[3,2-d]pyrimidine and thieno[3,2-d]pyrimidine c-nucleosides. Synthesis of “2′-deoxy-9-deazaadenosine” and of “9-deaza ara-A.” Journal Article
| Authors: | Rao, K. V. B.; Ren, W. Y.; Burchenal, J. H.; Klein, R. S. |
| Article Title: | Nucleosides 137. Synthetic modifications at the 2′-position of pyrrolo[3,2-d]pyrimidine and thieno[3,2-d]pyrimidine c-nucleosides. Synthesis of “2′-deoxy-9-deazaadenosine” and of “9-deaza ara-A.” |
| Abstract: | The syntheses and preliminary biological evaluation of several novel pyrrolo[3,2-d]pyrimidine and thieno[3,2-d]pyrimidine C-nucleosides incorporating the arabinofuranosyl or 2′-deoxyribofuranosyl sugar moiety are described. The 2′-deoxy thieno[3,2-d]pyrimidine C-3H nucleosides (15 and 16) were obtained from 7-(β-D-ribofuranosyl)-4-oxo-3H-thieno[3,2-d]pyrimidine (3) and its 4-SMe derivative 8. “2′-Deoxy-9- deazaadenosine” (31), “9-Deaza ara -A” (38) and the 2′-substituted arabinosyl pyrrolo[3,2-d]pyrimidine C-nucleosides (42–44) were synthesized from 4-amino-7-(2,3-O-isopropylidene-5-O-trityl-β-D-ribo-furanosyl)-5H-pyrrolo[3,2-d]pyrimidine (21). © 1986, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | nonhuman; mouse; in vitro study; drug screening; drug synthesis; drug cytotoxicity; nuclear magnetic resonance; drug identification; intoxication; drug comparison; new drug; leukemia l 1210; c nucleoside; 9 deazadeoxyadenosine; blood and hemopoietic system; drug analysis; p 815 cell; 9 deazaadenosine; 9 deazavidarabine; pyrrolo[3,2 d]pyrimidine derivative |
| Journal Title: | Nucleosides & Nucleotides |
| Volume: | 5 |
| Issue: | 5 |
| ISSN: | 0732-8311 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1986-01-01 |
| Start Page: | 539 |
| End Page: | 569 |
| Language: | English |
| DOI: | 10.1080/07328318608068696 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus |
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