Synthesis of oligodeoxynucleotides containing the C-nucleoside and 2'- deoxy-2’-fluoro-ara-nucleoside moieties by the H-phosphonate method Journal Article
| Authors: | Rosenberg, I.; Soler, J. F.; Tocik, Z.; Ren, W. Y.; Ciszewski, L. A.; Kois, P.; Pankiewicz, K.; Spassova, M.; Watanabe, K. A. |
| Article Title: | Synthesis of oligodeoxynucleotides containing the C-nucleoside and 2'- deoxy-2’-fluoro-ara-nucleoside moieties by the H-phosphonate method |
| Abstract: | A module type, computer-controlled, multipurpose synthesizer displaying a novel device for the transport of liquids, was constructed and used in the synthesis of oligomers containing some C-nucleosides and 2,-deoxy-2,-fluoro-ara-nucleoside moieties. H-Phosphonate method was applied in terms of a further adjustment of construction features of the synthesizer versus chemistry of the process. Results of preliminary studies on the effects of the modified nucleosides on the stability of duplexes showed a clear tendency of destabilization of duplexes in the case of C-nucleosides while fluorinated nucleosides in most cases stabilize the formed duplexes. © 1993, Taylor & Francis Group, LLC. All rights reserved. |
| Keywords: | review; drug synthesis; phosphonic acid derivative; molecular stability; computer system; clevudine; ara; oligodeoxynucleotide derivative; c nucleoside; nucleic acid synthesis |
| Journal Title: | Nucleosides & Nucleotides |
| Volume: | 12 |
| Issue: | 3-4 |
| ISSN: | 0732-8311 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 1993-04-01 |
| Start Page: | 381 |
| End Page: | 401 |
| Language: | English |
| DOI: | 10.1080/07328319308017834 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Wu-Yun Ren's name is misspelled on the original publication -- Article -- Export Date: 1 March 2019 -- Source: Scopus |
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43Pankiewicz
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