Distribution of renal tumor growth rates determined by using serial volumetric CT measurements Journal Article
| Authors: | Zhang, J.; Kang, S. K.; Wang, L.; Touijer, A.; Hricak, H. |
| Article Title: | Distribution of renal tumor growth rates determined by using serial volumetric CT measurements |
| Abstract: | Purpose: To retrospectively determine the distribution of growth rates across different sizes and subtypes of renal cortical tumors by assessing tumor volume and maximum tumor diameter at serial volumetric computed tomographic (CT) examinations. Materials and Methods: The institutional review board approved this retrospective, HIPAA-compliant study. Fifty-three of 2304 patients (34 men, 19 women; mean age, 67 years ± 10 [standard deviation; range, 39-88 years) who underwent nephrectomy from 1989 to 2006 did not receive preoperative chemotherapy or radiation therapy and underwent at least two preoperative contrast material-enhanced CT examinations (at least 3 months apart) with identical section thickness that was no more than one-fifth of longitudinal tumor diameter. Tumor volume and maximum diameter were measured on CT scans. Reciprocal of doubling time (DT) (RDT) was calculated. Analysis of variance and Student t tests were performed. Results: Thirty-two clear cell carcinomas, 10 papillary carcinomas, six chromophobe carcinomas, four oncocytomas, and one angiomyolipoma were analyzed. Median tumor size was 2.9 cm (range, 1-12 cm). Seven tumors did not increase in volume. DT ranged from -248 to 72 days (mean, 474 days; median, 811 days). Growth rate determined by using maximum diameter ranged from -10.8 to 33.2 mm/y (mean, 5.1 mm/y; median, 3.5 mm/y). Faster-growing tumors were more likely to be clear cell carcinomas, those of higher grade had higher growth rates. No significant correlation was found between RDT and tumor initial volume, subtype, or grade. Small renal tumors (≤3.5 cm) were similar to larger tumors in subtype and growth rate. Age at diagnosis correlated negatively with renal tumor growth rate (P = .03). Conclusion: Growth rates in renal tumors of different sizes, subtypes, and grades represent a wide range and overlap substantially. Small renal tumors appear to be similar to larger ones in nature. © RSNA, 2009. |
| Keywords: | adult; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; disease course; cancer staging; follow up; methodology; neoplasm staging; preoperative evaluation; computer assisted tomography; tumor volume; carcinoma, papillary; pathology; diagnostic imaging; retrospective study; histology; oncocytoma; kidney carcinoma; adenoma, oxyphilic; kidney neoplasms; kidney tumor; carcinoma, renal cell; tumor burden; angiomyolipoma; disease progression; contrast enhancement; measurement; radiography; clear cell carcinoma; tumor growth; papillary carcinoma; mathematical computing; tumor diagnosis; cone beam computed tomography; growth rate; kidney cortex; computed tomography scanner; periodic medical examination; cone-beam computed tomography |
| Journal Title: | Radiology |
| Volume: | 250 |
| Issue: | 1 |
| ISSN: | 0033-8419 |
| Publisher: | Radiological Society of North America, Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 137 |
| End Page: | 144 |
| Language: | English |
| DOI: | 10.1148/radiol.2501071712 |
| PUBMED: | 19092093 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 30 November 2010" - "CODEN: RADLA" - "Source: Scopus" |
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