What CT characteristics of lepidic predominant pattern lung adenocarcinomas correlate with invasiveness on pathology? Journal Article

   


Authors: Aherne, E. A.; Plodkowski, A. J.; Montecalvo, J.; Hayan, S.; Zheng, J.; Capanu, M.; Adusumilli, P. S.; Travis, W. D.; Ginsberg, M. S.
Article Title: What CT characteristics of lepidic predominant pattern lung adenocarcinomas correlate with invasiveness on pathology?
Abstract: Objectives: The International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society lung adenocarcinoma classification in 2011 defined three lepidic predominant patterns including adenocarcinoma in situ, minimally invasive adenocarcinoma and lepidic predominant adenocarcinoma. We sought to correlate the radiology and pathology findings and identify any computed tomography (CT) features which can be associated with invasive growth. Materials and methods: An institutional review board approved, retrospective study was conducted evaluating 63 patients with resected, pathologically confirmed, adenocarcinomas with predominant lepidic patterns. Preoperative CT images of the nodules were assessed using quantitative and qualitative radiographic descriptors while blinded to pathologic sub-classification and size. Maximum diameter was measured after evaluation of the axial, sagittal and coronal planes. Radiologic − pathologic associations were examined using Fisher's exact test, the Kruskal-Wallis test and the Spearman correlation coefficient (ρ). Results and conclusion: Increasing maximum diameter of the whole lesion (ground glass and solid component) on CT was significantly associated with invasiveness (p =.003), as was the maximum pathologic specimen diameter (p =.008). Larger diameter of the solid component on CT was also found in lepidic predominant adenocarcinoma compared to minimally invasive adenocarcinoma (median 10.5 vs 2 mm, p =.005). More invasive tumors had higher visual estimated percentage solid component compared to whole lesion measurement on CT (p =.014). CT and pathologic measurements were positively correlated, although only moderately (ρ =.66) for the maximum whole lesion size and fair (ρ =.49) for solid/invasive component maximum measurements. Larger whole lesion size and solid component size of lepidic predominant pattern adenocarcinomas are associated with lesion invasiveness, although radiologic and pathologic lesion measurements are only fair-moderately positively correlated. © 2018 Elsevier B.V.
Keywords: pathology; lung adenocarcinoma; radiology; computed tomography; lepidic predominant adenocarcinoma
Journal Title: Lung Cancer
Volume: 118
ISSN: 0169-5002
Publisher: Elsevier Ireland Ltd.  
Date Published: 2018-04-01
Start Page: 83
End Page: 89
Language: English
DOI: 10.1016/j.lungcan.2018.01.013
PROVIDER: scopus
PMCID: PMC5912171
PUBMED: 29572008
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041821606&doi=10.1016%2fj.lungcan.2018.01.013&partnerID=40&md5=59e8156d19ef0344c54633424fadcfe4
Notes: Article -- Export Date: 1 March 2018 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Junting Zheng
    200 Zheng
  2. Michelle S Ginsberg
    234 Ginsberg
  3. Marinela Capanu
    385 Capanu
  4. William D Travis
    742 Travis
  5. Prasad S Adusumilli
    496 Adusumilli
  6. Andrew Joseph Plodkowski
    114 Plodkowski
  7. Joseph Montecalvo
    43 Montecalvo
  8. Sumar Hayan
    2 Hayan
  9. Alanna Julianne Emily Aherne
    4 Aherne
Related MSK Work