Significance of peritumoral vascularity on CT in evaluation of renal cortical tumor Journal Article
| Authors: | Zhang, J.; Lefkowitz, R. A.; Wang, L.; Ishill, N. M.; Moskowitz, C. S.; Russo, P.; Hricak, H. |
| Article Title: | Significance of peritumoral vascularity on CT in evaluation of renal cortical tumor |
| Abstract: | PURPOSE: To investigate whether the presence and degree of peritumoral vascularity may provide any diagnostic information regarding the histological subtypes of renal tumors. MATERIALS AND METHODS: Between January 2004 and March 2006, 214 patients (age, 19-94 years; 120 men, 94 women) with renal masses underwent total or partial nephrectomy and preoperative renal protocol computed tomography. Two radiologists retrospectively reviewed the computed tomographic exams in an independent and blinded fashion. The radiologists evaluated the presence of peritumoral vascularity and measured the largest vessel caliber. Fisher exact tests, multivariate logistic regression, and Wilcoxon rank-sum tests were performed for statistical analysis. RESULTS: Of 219 renal tumors (median size, 3.5 cm; range, 0.9-20.0 cm) included in this study, 112 (51%) were clear cell renal cell carcinoma, 34 (16%) were papillary, 32 (15%) were chromophobe, 17 (8%) were oncocytomas, 6 (3%) were lipid-poor angiomyolipomas, and 18 (8%) were other or unclassified renal tumors. The presence of peritumoral vascularity was significantly associated with tumor size within each subtype. For both readers, peritumoral vascularity was more frequently identified in clear cell carcinomas than in papillary renal carcinomas of similar size (P = 0.019 and 0.008, respectively). For one of the readers, chromophobe carcinomas were also significantly less frequently associated with peritumoral vascularity than clear cell carcinomas of similar size (P = 0.014). CONCLUSIONS: Clear cell carcinomas demonstrate peritumoral vascularity significantly more frequently than other malignant renal tumors of similar size. The presence of peritumoral vascularity may provide additional diagnostic information and improve therapeutic planning in some cases. © 2007 Lippincott Williams & Wilkins, Inc. |
| Keywords: | adult; controlled study; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; review; computer assisted tomography; tumor volume; logistic models; tomography, x-ray computed; oncocytoma; renal cell carcinoma; kidney carcinoma; kidney neoplasms; nephrectomy; statistical analysis; partial nephrectomy; radiologist; kidney tumor; carcinoma, renal cell; angiomyolipoma; multivariate logistic regression analysis; iohexol; cross-sectional studies; kidney cancer; papillary carcinoma; tumor vascularization; fisher exact test; statistics, nonparametric; ct; rank sum test; differentiation; diatrizoate; barium sulfate; renal tumor |
| Journal Title: | Journal of Computer Assisted Tomography |
| Volume: | 31 |
| Issue: | 5 |
| ISSN: | 0363-8715 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2007-09-01 |
| Start Page: | 717 |
| End Page: | 723 |
| Language: | English |
| DOI: | 10.1097/rct.0b013e318031521e |
| PUBMED: | 17895782 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: JCATD" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work