Solid renal cortical tumors: Differentiation with CT Journal Article

Authors: Zhang, J.; Lefkowitz, R. A.; Ishill, N. M.; Wang, L.; Moskowitz, C. S.; Russo, P.; Eisenberg, H.; Hricak, H.
Article Title: Solid renal cortical tumors: Differentiation with CT
Abstract: Purpose: To retrospectively determine if solid renal cortical tumors can be differentiated on computed tomographic (CT) images on the basis of their morphologic features and enhancement patterns. Materials and Methods: Institutional review board approval was obtained and the informed consent requirement was waived for this HIPAA-compliant study. Between January 2004 and September 2005, 193 consecutive patients (age range, 19-95 years; 112 men, 81 women) with renal masses underwent total or partial nephrectomy and preoperative renal CT. Two radiologists retrospectively reviewed CT studies in an independent and blinded fashion. The pattern and degree of enhancement, lesion contour, presence of neovascularity, and calcifications were evaluated. Fisher exact tests, Pearson χ2 tests, multivariate logistic regression, and Wilcoxon rank sum tests were performed. Results: Of the 198 renal tumors (median size, 3.4 cm; range, 1.1-20.0 cm) included in this study, 108 (55%) were clear cell renal cell carcinomas (RCCs); 30 (15%), papillary lesions; 24 (12%), chromophobe adenomas; 14 (7%), oncocytomas; six (3%), lipid-poor angiomyolipomas; and 16 (8%), other or unclassified renal tumors. Clear cell RCC most commonly manifested with a mixed enhancement pattern of both hypervascular soft-tissue components and low-attenuation areas that corresponded to necrotic or cystic changes (reader 1, 88% of clear cell tumors; reader 2, 79% of clear cell tumors). This pattern was highly predictive of clear cell RCC (odds ratio of 22 and 54 for readers 1 and 2, respectively, for comparison with homogeneous pattern), whereas the homogeneous and peripheral enhancing patterns were more predictive of less aggressive papillary and chromophobe lesions. Clear cell RCCs and oncocytomas tended to be hypervascular, chromophobe lesions and angiomyolipomas tended to enhance moderately, and papillary lesions were mostly hypovascular. Conclusion: Certain imaging features and the degree of enhancement may be helpful in differentiating subtypes of renal cortical tumors. © RSNA, 2007.
Keywords: adult; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; review; preoperative evaluation; computer assisted tomography; image analysis; diagnosis, differential; logistic models; differential diagnosis; tomography, x-ray computed; diagnostic imaging; retrospective study; oncocytoma; kidney carcinoma; kidney neoplasms; nephrectomy; kidney calcification; partial nephrectomy; kidney tumor; image enhancement; diagnostic value; angiomyolipoma; contrast enhancement; multivariate logistic regression analysis; chi-square distribution; iohexol; contrast media; clear cell carcinoma; chi square test; chromophobe adenoma; fisher exact test; rank sum test; radiographic image interpretation, computer-assisted; apparatus
Journal Title: Radiology
Volume: 244
Issue: 2
ISSN: 0033-8419
Publisher: Radiological Society of North America, Inc.  
Date Published: 2007-08-01
Start Page: 494
End Page: 504
Language: English
DOI: 10.1148/radiol.2442060927
PUBMED: 17641370
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 41" - "Export Date: 17 November 2011" - "CODEN: RADLA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Paul Russo
    531 Russo
  2. Chaya S. Moskowitz
    212 Moskowitz
  3. Jingbo Zhang
    37 Zhang
  4. Hedvig Hricak
    384 Hricak
  5. Liang Wang
    35 Wang
  6. Nicole Marie Leoce
    86 Leoce