MR imaging of renal cortical tumours: Qualitative and quantitative chemical shift imaging parameters Journal Article
| Authors: | Karlo, C. A.; Donati, O. F.; Burger, I. A.; Zheng, J.; Moskowitz, C. S.; Hricak, H.; Akin, O. |
| Article Title: | MR imaging of renal cortical tumours: Qualitative and quantitative chemical shift imaging parameters |
| Abstract: | Objectives: To assess qualitative and quantitative chemical shift MRI parameters of renal cortical tumours. Methods: A total of 251 consecutive patients underwent 1.5-T MRI before nephrectomy. Two readers (R1, R2) independently evaluated all tumours visually for a decrease in signal intensity (SI) on opposed- compared with in-phase chemical shift images. In addition, SI was measured on in- and opposed-phase images (SIIP, SIOP) and the chemical shift index was calculated as a measure of percentage SI change. Histopathology served as the standard of reference. Results: A visual decrease in SI was identified significantly more often in clear cell renal cell carcinoma (RCCs) (R1, 73 %; R2, 64 %) and angiomyolipomas (both, 80 %) than in oncocytomas (29 %, 12 %), papillary (29 %, 17 %) and chromophobe RCCs (13 %, 9 %; all, P < 0.05). Median chemical shift index was significantly greater in clear cell RCC and angiomyolipoma than in the other histological subtypes (both, P < 0.001). Interobserver agreement was fair for visual (kappa, 0.4) and excellent for quantitative analysis (concordance correlation coefficient, 0.80). Conclusions: A decrease in SI on opposed-phase chemical shift images is not an identifying feature of clear cell RCCs or angiomyolipomas, but can also be observed in oncocytomas, papillary and chromophobe RCCs. After excluding angiomyolipomas, a decrease in SI of more than 25 % was diagnostic for clear cell RCCs. Key Points: • Chemical shift MRI offers new information about fat within renal tumours. • Opposed-phase signal decrease can be observed in all renal cortical tumours. • A greater than 25 % decrease in signal appears to be diagnostic for clear cell RCCs © 2012 European Society of Radiology. |
| Keywords: | adolescent; adult; controlled study; aged; major clinical study; histopathology; nuclear magnetic resonance imaging; magnetic resonance imaging; image analysis; oncocytoma; renal cell carcinoma; kidney carcinoma; nephrectomy; kidney tumor; angiomyolipoma; kidney hemangiomyolipoma; quantitative analysis; image quality; papilloma; qualitative analysis; nuclear magnetic resonance scanner; kidney cortex; radiological parameters; chemical shift imaging |
| Journal Title: | European Radiology |
| Volume: | 23 |
| Issue: | 6 |
| ISSN: | 0938-7994 |
| Publisher: | Springer |
| Date Published: | 2013-06-01 |
| Start Page: | 1738 |
| End Page: | 1744 |
| Language: | English |
| DOI: | 10.1007/s00330-012-2758-x |
| PROVIDER: | scopus |
| PUBMED: | 23300041 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 July 2013" - "CODEN: EURAE" - "Source: Scopus" |
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