Clonal expansion of innate and adaptive lymphocytes Review

  


Authors: Adams, N. M.; Grassmann, S.; Sun, J. C.
Review Title: Clonal expansion of innate and adaptive lymphocytes
Abstract: One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of individual cell clones that encounter their cognate antigen. More recently, however, there is growing evidence for the clonal expansion of innate lymphocytes, particularly in the context of pathogen challenge. Clonal expansion not only serves to amplify the number of specific lymphocytes to mount a robust protective response to the pathogen at hand but also results in selection and differentiation of the responding lymphocytes to generate a multitude of cell fates. Here, we summarize the evidence for clonal expansion in innate lymphocytes, which has primarily been observed in natural killer (NK) cells responding to cytomegalovirus infection, and consider the requirements for such a response in NK cells in light of those for T cells. Furthermore, we discuss multiple aspects of heterogeneity that both contribute to and result from the fundamental immunological process of clonal expansion, highlighting the parallels between innate and adaptive lymphocytes, with a particular focus on NK cells and CD8+ T cells. © 2020, Springer Nature Limited.
Keywords: review; nonhuman; cd8+ t lymphocyte; cell maturation; inflammation; cell fate; cell heterogeneity; lymphocyte differentiation; transcription regulation; natural killer cell; cell clone; adaptive immunity; lymphocyte; cytomegalovirus infection; cell expansion; cell selection; cell cloning; lymphoid cell; biodiversity; clonal expansion; human; priority journal; innate lymphocyte; adaptive lymphocyte
Journal Title: Nature Reviews Immunology
Volume: 20
Issue: 11
ISSN: 1474-1733
Publisher: Nature Publishing Group  
Date Published: 2020-11-01
Start Page: 694
End Page: 707
Language: English
DOI: 10.1038/s41577-020-0307-4
PUBMED: 32424244
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085219981&doi=10.1038%2fs41577-020-0307-4&partnerID=40&md5=4a9399d0c892a00f5c7a43872afdb914
Notes: Review -- Export Date: 1 December 2020 -- Source: Scopus
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MSK Authors
  1. Joseph C Sun
    131 Sun
  2. Nicholas M Adams
    19 Adams
  3. Simon Andreas Grassmann
    29 Grassmann
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