Generation of natural killer cell memory during viral infection Journal Article
| Authors: | O'sullivan, T. E.; Sun, J. C. |
| Article Title: | Generation of natural killer cell memory during viral infection |
| Abstract: | Immunological memory is classically regarded as an attribute of antigen-specific T and B lymphocytes of the adaptive immune system. Cells of the innate immune system, including natural killer (NK) cells, have been considered short-lived cytolytic cells that can rapidly respond against pathogens in an antigen-independent manner and then die off. However, NK cells have recently been described to possess traits of adaptive immunity, such as clonal expansion after viral antigen exposure to generate long-lived memory cells. In this review, we will discuss the current evidence for viral-induced NK cell memory in both mice and humans. © 2015 S. Karger AG, Basel. |
| Keywords: | review; nonhuman; cd8+ t lymphocyte; cell proliferation; apoptosis; natural killer cell; virus antigen; virus infection; adaptive immunity; memory cell; lymphoid progenitor cell; cell activation; cell expansion; cytomegalovirus; immunological memory; memory t lymphocyte; viral clearance; natural killer cells; human; priority journal |
| Journal Title: | Journal of Innate Immunity |
| Volume: | 7 |
| Issue: | 6 |
| ISSN: | 1662-811X |
| Publisher: | S. Karger AG |
| Date Published: | 2015-10-01 |
| Start Page: | 557 |
| End Page: | 562 |
| Language: | English |
| DOI: | 10.1159/000375494 |
| PROVIDER: | scopus |
| PMCID: | PMC4581887 |
| PUBMED: | 25823611 |
| DOI/URL: | |
| Notes: | Export Date: 2 December 2015 -- Source: Scopus |
