NK cell responses redefine immunological memory Journal Article

   


Authors: Adams, N. M.; O'Sullivan, T. E.; Geary, C. D.; Karo, J. M.; Amezquita, R. A.; Joshi, N. S.; Kaech, S. M.; Sun, J. C.
Article Title: NK cell responses redefine immunological memory
Abstract: Immunological memory has traditionally been regarded as a unique trait of the adaptive immune system. Nevertheless, there is evidence of immunological memory in lower organisms and invertebrates, which lack an adaptive immune system. Despite their innate ability to rapidly produce effector cytokines and kill virally infected or transformed cells, NK cells also exhibit adaptive characteristics such as clonal expansion, longevity, self-renewal, and robust recall responses to antigenic or nonantigenic stimuli. In this review, we highlight the intracellular and extracellular requirements for memory NK cell generation and describe the emerging evidence formemory precursor NK cells and their derivation. © Copyright 2016 by The American Association of Immunologists, Inc.
Journal Title: Journal of Immunology
Volume: 197
Issue: 8
ISSN: 0022-1767
Publisher: The American Association of Immunologists, Inc  
Date Published: 2016-10-15
Start Page: 2963
End Page: 2970
Language: English
DOI: 10.4049/jimmunol.1600973
PROVIDER: scopus
PMCID: PMC5108457
PUBMED: 27824591
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991486014&partnerID=40&md5=d7c3ec32752e7abe0ab25d3d37e05f0b
Notes: Review -- Export Date: 2 November 2016 -- Source: Scopus
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MSK Authors
  1. Joseph C Sun
    131 Sun
  2. Jenny Karo
    5 Karo
  3. Timothy Edward O'Sullivan
    13 O'Sullivan
  4. Clair Geary
    14 Geary
  5. Nicholas M Adams
    19 Adams
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