Epigenetic control of innate and adaptive immune memory Journal Article


Authors: Lau, C. M.; Adams, N. M.; Geary, C. D.; Weizman, O. E.; Rapp, M.; Pritykin, Y.; Leslie, C. S.; Sun, J. C.
Article Title: Epigenetic control of innate and adaptive immune memory
Abstract: Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate that differentiating and 'memory' NK cells possess distinct chromatin accessibility states and that their epigenetic profiles reveal a 'poised' regulatory program at the memory stage. Furthermore, we elucidate how individual STAT transcription factors differentially control epigenetic and transcriptional states early during infection. Finally, concurrent chromatin profiling of the canonical CD8(+) T cell response against the same infection demonstrated parallel and distinct epigenetic signatures defining NK cells and CD8(+) T cells. Overall, our study reveals the dynamic nature of epigenetic modifications during the generation of innate and adaptive lymphocyte memory.
Keywords: transcription factors; chromatin; cytomegalovirus; activation; viral-infection; natural-killer-cells; cd8(+) t-cells; nk cells; identity; terminal differentiation
Journal Title: Nature Immunology
Volume: 19
Issue: 9
ISSN: 1529-2908
Publisher: Nature Publishing Group  
Date Published: 2018-09-01
Start Page: 963
End Page: 972
Language: English
ACCESSION: WOS:000442365100018
DOI: 10.1038/s41590-018-0176-1
PROVIDER: wos
PUBMED: 30082830
PMCID: PMC6225771
Notes: Article -- Source: Wos
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MSK Authors
  1. Joseph C Sun
    92 Sun
  2. Christina Leslie
    142 Leslie
  3. Moritz Enzo Rapp
    11 Rapp
  4. Clair   Geary
    13 Geary
  5. Nicholas M Adams
    17 Adams
  6. Colleen M Lau
    15 Lau