RNA helicases are hubs that orchestrate exosome-dependent 3′-5′ decay Journal Article
| Authors: | Weick, E. M.; Lima, C. D. |
| Article Title: | RNA helicases are hubs that orchestrate exosome-dependent 3′-5′ decay |
| Abstract: | The RNA exosome is a conserved complex of proteins that mediates 3′–5′ RNA processing and decay. Its functions range from processing of non-coding RNAs such as ribosomal RNAs and decay of aberrant transcripts in the nucleus to cytoplasmic mRNA turnover and quality control. Ski2-like RNA helicases translocate substrates to exosome-associated ribonucleases and interact with the RNA exosome either directly or as part of multi-subunit helicase-containing complexes that identify and target RNA substrates for decay. Recent structures of these helicases with their RNA-binding partners or the RNA exosome have advanced our understanding of a system of modular and mutually exclusive contacts between the exosome and exosome-associated helicase complexes that shape the transcriptome by orchestrating exosome-dependent 3′–5′ decay. © 2020 The Author(s) |
| Keywords: | review; genetic transcription; messenger rna; 5' untranslated region; gene interaction; 3' untranslated region; ribosome rna; untranslated rna; rna processing; rna helicase; transcriptome; rna binding; ribosome; exosome; human; priority journal |
| Journal Title: | Current Opinion in Structural Biology |
| Volume: | 67 |
| ISSN: | 0959-440X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2021-04-01 |
| Start Page: | 86 |
| End Page: | 94 |
| Language: | English |
| DOI: | 10.1016/j.sbi.2020.09.010 |
| PUBMED: | 33147539 |
| PROVIDER: | scopus |
| PMCID: | PMC8087718 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 December 2020 -- Source: Scopus |
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