RNA helicases are hubs that orchestrate exosome-dependent 3′-5′ decay Journal Article

Authors: Weick, E. M.; Lima, C. D.
Article Title: RNA helicases are hubs that orchestrate exosome-dependent 3′-5′ decay
Abstract: The RNA exosome is a conserved complex of proteins that mediates 3′–5′ RNA processing and decay. Its functions range from processing of non-coding RNAs such as ribosomal RNAs and decay of aberrant transcripts in the nucleus to cytoplasmic mRNA turnover and quality control. Ski2-like RNA helicases translocate substrates to exosome-associated ribonucleases and interact with the RNA exosome either directly or as part of multi-subunit helicase-containing complexes that identify and target RNA substrates for decay. Recent structures of these helicases with their RNA-binding partners or the RNA exosome have advanced our understanding of a system of modular and mutually exclusive contacts between the exosome and exosome-associated helicase complexes that shape the transcriptome by orchestrating exosome-dependent 3′–5′ decay. © 2020 The Author(s)
Keywords: review; genetic transcription; messenger rna; 5' untranslated region; gene interaction; 3' untranslated region; ribosome rna; untranslated rna; rna processing; rna helicase; transcriptome; rna binding; ribosome; exosome; human; priority journal
Journal Title: Current Opinion in Structural Biology
Volume: 67
ISSN: 0959-440X
Publisher: Elsevier Inc.  
Date Published: 2021-04-01
Start Page: 86
End Page: 94
Language: English
DOI: 10.1016/j.sbi.2020.09.010
PUBMED: 33147539
PROVIDER: scopus
PMCID: PMC8087718
Notes: Review -- Export Date: 1 December 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Christopher D Lima
    100 Lima
  2. Eva-Maria Weick
    5 Weick